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Database: UniProt
Entry: Q6CDS6
LinkDB: Q6CDS6
Original site: Q6CDS6 
ID   ROK1_YARLI              Reviewed;         547 AA.
AC   Q6CDS6;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   16-OCT-2019, entry version 95.
DE   RecName: Full=ATP-dependent RNA helicase ROK1;
DE            EC=3.6.4.13;
GN   Name=ROK1; OrderedLocusNames=YALI0B21538g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida
OS   lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
CC       subunit biogenesis. Required for the processing and cleavage of
CC       35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 snoRNA and is associated with the
CC       90S and 40S pre-ribosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR382128; CAG83439.1; -; Genomic_DNA.
DR   RefSeq; XP_501186.1; XM_501186.1.
DR   SMR; Q6CDS6; -.
DR   PRIDE; Q6CDS6; -.
DR   EnsemblFungi; CAG83439; CAG83439; YALI0_B21538g.
DR   GeneID; 2907486; -.
DR   KEGG; yli:YALI0B21538g; -.
DR   HOGENOM; HOG000242486; -.
DR   InParanoid; Q6CDS6; -.
DR   KO; K14779; -.
DR   OMA; ICTTPRF; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    547       ATP-dependent RNA helicase ROK1.
FT                                /FTId=PRO_0000232308.
FT   DOMAIN      142    324       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      336    498       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     155    162       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       111    139       Q motif.
FT   MOTIF       272    275       DEAD box.
SQ   SEQUENCE   547 AA;  60554 MW;  9CE6EE186442D5DE CRC64;
     MDIFKVLSRG ATIQRNGKHR KDLTLLNHAA PKDTQDNVDI EVARETDFFK TKTDTYSKKR
     VAEEAELDNE EEEEAPPPII STPEEAVVFR NKHKINITGE DSPLPIGSFE DLITRFNLHP
     YLLANLKKNK YTDPTPIQCE SIPTMLNGRD LIACAPTGSG KTMAYSIPMV EMLGKKKGSK
     DAKKGIKALV VAPTKELASQ IFNAVFSLCV GVGKKKDELK PCLLDKSTAD KLRNGKVSSQ
     KYDICITTPL RLVSALNDGS LDLGSLDLVI FDEADKLFEK GFATQVDDIL AACPSGIQKT
     LFSATIPASV EQLANSIMST DPLRIIIGNK QAAAQTVEQK LVYAGNEEGK LVAIRQMARE
     GQLVAPVIIF LQSIDRAKAL FKELVFDGIN VDQIHGDMTA AKRASVIDRF RNGEVWVLIC
     TDVLARGIDF RGINLVINYD VPQSAQSYVH RIGRTGRAGR LGKAVTFFTK EDATNVKVVV
     NVMKQSGQEV PDWLNNLAPL TQKERDNIKN RPIKRKKIST QHALANNKKK RAKQQMKGLK
     KMKKDDE
//
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