ID Q6CFL1_YARLI Unreviewed; 3277 AA.
AC Q6CFL1;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 2.
DT 24-JAN-2024, entry version 127.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=YALI0_B05940g {ECO:0000313|EMBL:CAG82782.2};
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591 {ECO:0000313|EMBL:CAG82782.2, ECO:0000313|Proteomes:UP000001300};
RN [1] {ECO:0000313|EMBL:CAG82782.2, ECO:0000313|Proteomes:UP000001300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150 {ECO:0000313|Proteomes:UP000001300};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
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DR EMBL; CR382128; CAG82782.2; -; Genomic_DNA.
DR RefSeq; XP_500551.2; XM_500551.2.
DR STRING; 284591.Q6CFL1; -.
DR EnsemblFungi; CAG82782; CAG82782; YALI0_B05940g.
DR GeneID; 2907209; -.
DR KEGG; yli:YALI0B05940g; -.
DR VEuPathDB; FungiDB:YALI0_B05940g; -.
DR HOGENOM; CLU_000215_0_1_1; -.
DR InParanoid; Q6CFL1; -.
DR OMA; DCHFSRE; -.
DR OrthoDB; 164548at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001300; Chromosome B.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF06012; DUF908; 1.
DR Pfam; PF06025; DUF913; 2.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF14377; UBM; 2.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS50237; HECT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001300};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 421..451
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2941..3277
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1793..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1869..1946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2163..2193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2209..2236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2822..2843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1799..1824
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1869..1888
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1889..1903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1904..1943
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3244
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3277 AA; 364870 MW; 220C890D8A10BA47 CRC64;
MRTLTPTQVA RLDVQTQPDL RHFINDVTSA NESDLPELLD SFRLKGWERP KGNLYLWYRV
LERFEKIMES IVGDKTDIIN VDDAQERVLV SLLSFSAFLL EHCSNRSLYS STKYLSSLLS
CSSLPVLNAT LSVCIQISQR YSDTRGGRAA TAAIDIHKML KIASLFAANI APLANSDKIS
LVDFVTDDKK WPDQLRAVSI EYFASKVRDR EGQTAQSTPT KFKGAASSAL STTNTKTGLQ
TFTISSSEMK KLSVMEAYER ATTVLPQELH LDALMYIRAA KSFSTGASSR VPLVSAKCMA
ITFAVFLLTE NVLATKFYAP YPNLVQHLVD LLNPDYKVPN ELRSNAIEGL YAMARQRTKL
HEILTCLSAN VSHGLLMHII RTLISDLKER RLDEKYASDL CGLVVNLCVS SSTGQMLVSA
GLVPALLELI DNDSDYLHMK NVALTLLGQL TLSAPAAFTA LINANGVDLI ARLIKNEVDY
DLDNHGPVPT HCRVDYQISY YRAGWLKTIL KFVLQVMPTG GNAERLRNLI DSSTLLSSLG
AILQSPQVFG STIVSVSLGL IITVLHNEPT SYSIISEAGL IDIFFACAEE IMSLSSNDIL
MAGLNAIGAI CLNPDGLERA SSEFDYSLIF KVLEDPTRSE ELTRHDLAAE LGAMVDELIR
HNPKLLPSVM EAVDKTAASL AAGVSHESTD TKKTDADDSE RAFVIDNFGR FFDCLIANER
ACDYFVKDNG FTHLLDIITL GDMPYDYGTS EAVNSLNDGL KHLSQRDEEG LVEVYDRKFG
GLLHNTDSEF YKFWKSEPGW DTSKIPTCSP ELLNQLTSVH SLLNSYEIVF DWAAQLKFVE
TKNPVEIFEL IESLYARASW EIVRISNSVP EDWKKAARLH YFSIAFGPSR KLEEDKKKQI
AEIEEKLPAD SEYWDLKQYW FVLNGITMAT LRCLSNVAKL ISAKRLVDHT TNKKLALNIA
DWVAKGLINN FNYLGIILHS DLPLKARSGY CVYVIAALRE TMLSSLRGGA STLTNSASLR
TSVFAPFRQA GGLEKLLEVL HYFWGHMEDG DTPEEAAEAK NLSRDEFESR EFKKPATLTV
NRILEFLLSL VTKECIVDSS FTLTLNTGEE RPYFDGGQFL VENKLAVLTG IKPLLLDKET
QRRAGARVFE WLLQLVSRLT IRLGEPASSD LNLVPTVLSP QFCTPSDYKV DFLVEQLEFS
IEDAKKKLID AGDNLGKVVK TAGKADIALP EVPKIDVWVP HAPDGTPLLT VAQLNTLRAN
LGNSLQERSL EFLEKHADHA SAVQELFSTP SDDLLEVLTQ GLDKGIPGRY ELIALSIQDD
RNREKFLKRG MYTLEWAQAY MQAHDPDFMS RPEFVHFLAV YERCYFVATE YPLEEAKHLY
AEVSHKFTDY SGMVVSEEAI EYVFSKLLAI EKFSESDTLL AVSRVLALYT TKFQYSDRIR
GAPVLQAMLK GIREFPDAAH MDSIQQTVLV LLRHCTETPT SIQNIIAHKL GQSSRAPIAN
LMQQYSYLYA RSPEYFILTA KRTLTCDVKH FPEVKPKKVE PLTAEVEHCG IMELLTTEIT
SLGNSWVPEP SDNVEHPAEP KDYPELAYLT FLLNCMTELL GAYADSKLEF VSLGRKKHGL
LSYFLTKLLY FSTAANEPDN TMTRARMSVS ASATSCLHAL VSSTQERDFD ADSTEKRDLV
MVRKALLDTV MRLLREATHL DTLDKRYTRY AVLLDLCHKL LSAKTLSTAT NSAAIASEHA
QQDSAEFALV MYDKHFAKSV TALIADLDLN FPGAKKVAKT LLRPIHRLSH LTMENPDALD
RGEDDDDSES EDDESEDDDS DDDTPPQNIF QNSTLGMFEA EANSGDEEMD EIGSDHSELD
DDDMEELEEP LYLDQEEDDS DLDLDDMSDD DHVSDHVAES DIDEVIAMEE GEDEWESYSE
EELGEEELED ELDFSEAEPA GEQEEGDAIG GVRDLIAALG NPSTPPPPPD YAIDLDSTDE
EELQEANSLF VPPPGHSGAV GGHPLLAGRG GNGRSLSMSY TRNAMNLSAI NNPMDNLLER
MVSRAVTGPD GGSFTIGIGS SNGVQIQRNV EALLTSVGGY RRPRKAGWDA KLLRFEASST
VIRWTAFARM FDIVKQRGVC WRAVAPIMNA IGPPVEAEIE AREQAQREAM QGRLAQEAVI
VESSEDEDMV SAASTDDLMG GQEDVEEDEE EERDEALDLA EAIMGHAEEV DDEDDDVSVG
TEADQLPESS GPARDPVYVT ISGRQVDISG LDIDPTFLEA LPEDMREEVV LQHIRESELD
DSVISTLPDN MRAELRPVTL GQADSQDFAT FLGTLDSNLR HTILMEQDEA TLNALPDELV
AEARRLRVRQ APLVMDQADD EDDDDPGTED DTAMIDDAVT STLGVATTAT TPHQRRHTKK
VDVFAARNFV DKSGITALIR LLYLPQGSAS RDFLHELLLN VVRNRQARAD VISILLSILQ
DGCRDRASLE RSFANLTTTS NVQGTPKSPI KAGLGSASSE LSTDVTPMTV TLQVLDALSY
LIRNNAHIRH YFLTEHEVPV GHTRVKRKKA LKSMKYPVNI LFGLLKNPVV TERSHAMEVL
SIMLQEATRP LQAKRRASMN VAAEAAALAR EETRAEAASS SGAVSDTAMV IDEPETEGVT
TTVQAKKSLK DLSPYIPSGN LSLVTQILTA NECSSLTFQQ TLSCMQNLLH IDNAVKVFSS
QLSSQAIRLG KTLITDLVNL NSLIHTPGNT IQGSALSKFS LASSDQAKLL RVLTAIDILF
DKRGETKVNI YNSLTFGPLW GALSDVLGYV AEHPDLIHVA TALLPLMEAL MVVCKHSRVT
ERSAGGAGGN HPGNSPTDHS THKYSARSYD FANEPIENLF FSFTDEHRKI LNLMVRNNPK
LMSGSFSILV KNPKVLEFDN KRNYFNRKIH SSNQSDGATI NLNVRRDQVF LDSYKSMYFK
SAAEIRSGKL NIHFSGEEGV DAGGVTREWY QVLARQMFNP DYALFTPVAS DTTTFHPNRT
SWVNPEHLSF FKFIGRIIGK AIFDQRLLDC HFSRAVYKKI LGRGVSLKDM ETLDIEYHKS
LVWMLENDIT DIITETMSIE TEDYGEKKTI DLMPDGRNIA VDESNKAEFV QRVVEYRLIT
SVEEQLEHFL QGFHDIIPKE LVSIFNEQEL ELLICGLPEI DVDDWRNNTV YTNYSASSPQ
IQWFWRSIRS FDDEERAKLL QFVTGTSKVP LDGFKELEGM NGPTKFNIHR AYGNNERLPS
SHTCFNQLDL PEYDSYETLR GSLLLAITEG REGFGFA
//