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Database: UniProt
Entry: Q6CL12_KLULA
LinkDB: Q6CL12_KLULA
Original site: Q6CL12_KLULA 
ID   Q6CL12_KLULA            Unreviewed;       364 AA.
AC   Q6CL12;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   08-MAY-2019, entry version 92.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=KLLA0_F06556g {ECO:0000313|EMBL:CAG98085.1};
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
OS   1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590 {ECO:0000313|Proteomes:UP000000598};
RN   [1] {ECO:0000313|EMBL:CAG98085.1, ECO:0000313|Proteomes:UP000000598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37 {ECO:0000313|Proteomes:UP000000598};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CR382126; CAG98085.1; -; Genomic_DNA.
DR   RefSeq; XP_455377.1; XM_455377.1.
DR   STRING; 28985.XP_455377.1; -.
DR   EnsemblFungi; CAG98085; CAG98085; KLLA0_F06556g.
DR   GeneID; 2895039; -.
DR   KEGG; kla:KLLA0_F06556g; -.
DR   eggNOG; ENOG410IF83; Eukaryota.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   InParanoid; Q6CL12; -.
DR   KO; K01626; -.
DR   OMA; CIGWEAT; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000598};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361}.
FT   DOMAIN       49    345       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   364 AA;  39277 MW;  23D337804C568CDF CRC64;
     MSQTPTPMFH EQEDVRILGY DPLVSPALLQ AQVPASQECL ETAQKGRKES IDIITGKDDR
     VLVVVGPCSI HDLKEAQDYA KGLKALSDEL KGDLCIIMRA YLEKPRTTVG WKGLINDPDV
     DNTYNINKGL QVSRQLFVNL TSLGLPIGSE MLDTISPQYL ADLLSFGAIG ARTTESQLHR
     ELASGLSFPV GFKNGTDGTL GVALDAVQAA SHSHHFMGVT KHGVAAITTT KGNEHCFVIL
     RGGKQGTNYD SVSVAEAKKA LPPTGVLMID YSHGNSNKDF RNQPKVNDAV CEQIANGEDK
     IIGVMIESHI NEGKQSIPAE GKAGLKYGVS ITDGCISLET TAEVLRKLAA AVRARRELKK
     KNTE
//
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