GenomeNet

Database: UniProt
Entry: Q6CNL2
LinkDB: Q6CNL2
Original site: Q6CNL2 
ID   Q6CNL2_KLULA            Unreviewed;        82 AA.
AC   Q6CNL2;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   07-APR-2021, entry version 110.
DE   RecName: Full=40S ribosomal protein S27 {ECO:0000256|RuleBase:RU000671};
GN   ORFNames=KLLA0_E11661g {ECO:0000313|EMBL:CAG99564.1};
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590 {ECO:0000313|Proteomes:UP000000598};
RN   [1] {ECO:0000313|EMBL:CAG99564.1, ECO:0000313|Proteomes:UP000000598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37 {ECO:0000313|Proteomes:UP000000598};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA   Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA   Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2] {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS).
RX   PubMed=25417110; DOI=10.1016/j.cell.2014.10.001;
RA   Hussain T., Llacer J.L., Fernandez I.S., Munoz A., Martin-Marcos P.,
RA   Savva C.G., Lorsch J.R., Hinnebusch A.G., Ramakrishnan V.;
RT   "Structural changes enable start codon recognition by the eukaryotic
RT   translation initiation complex.";
RL   Cell 159:597-607(2014).
RN   [3] {ECO:0007829|PDB:3JAM, ECO:0007829|PDB:3JAP}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS) IN COMPLEX WITH ZINC.
RX   PubMed=26212456; DOI=10.1016/j.molcel.2015.06.033;
RA   Llacer J.L., Hussain T., Marler L., Aitken C.E., Thakur A., Lorsch J.R.,
RA   Hinnebusch A.G., Ramakrishnan V.;
RT   "Conformational differences between open and closed states of the
RT   eukaryotic translation initiation complex.";
RL   Mol. Cell 59:399-412(2015).
RN   [4] {ECO:0007829|PDB:5IT7, ECO:0007829|PDB:5IT9}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) IN COMPLEX WITH ZINC.
RX   PubMed=27159451; DOI=10.7554/eLife.13567;
RA   Murray J., Savva C.G., Shin B.S., Dever T.E., Ramakrishnan V.,
RA   Fernandez I.S.;
RT   "Structural characterization of ribosome recruitment and translocation by
RT   type IV IRES.";
RL   Elife 5:0-0(2016).
RN   [5] {ECO:0007829|PDB:6FYX, ECO:0007829|PDB:6FYY}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.05 ANGSTROMS).
RX   PubMed=30475211; DOI=10.7554/eLife.39273;
RA   Llacer J.L., Hussain T., Saini A.K., Nanda J.S., Kaur S., Gordiyenko Y.,
RA   Kumar R., Hinnebusch A.G., Lorsch J.R., Ramakrishnan V.;
RT   "Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal
RT   subunit to promote start-codon recognition.";
RL   Elife 7:0-0(2018).
RN   [6] {ECO:0007829|PDB:6GSM, ECO:0007829|PDB:6GSN}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.75 ANGSTROMS) OF 2-82.
RA   Llacer J.L., Hussain T., Gordiyenko Y., Ramakrishnan V.;
RT   "Towards a model of eIF3 on the 40S subunit interface in eukaryotic
RT   translation initiation.";
RL   Submitted (JUN-2018) to the PDB data bank.
RN   [7] {ECO:0007829|PDB:6UZ7}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX   PubMed=31900355; DOI=10.1073/pnas.1916436117;
RA   Huang B.Y., Fernandez I.S.;
RT   "Long-range interdomain communications in eIF5B regulate GTP hydrolysis and
RT   translation initiation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:1429-1437(2020).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU000671};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU000671};
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS27 family.
CC       {ECO:0000256|ARBA:ARBA00010919, ECO:0000256|RuleBase:RU000671}.
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DR   EMBL; CR382125; CAG99564.1; -; Genomic_DNA.
DR   RefSeq; XP_454477.1; XM_454477.1.
DR   PDB; 3J80; EM; 3.75 A; b=1-82.
DR   PDB; 3J81; EM; 4.00 A; b=1-82.
DR   PDB; 3JAM; EM; 3.46 A; b=1-82.
DR   PDB; 3JAP; EM; 4.90 A; b=1-82.
DR   PDB; 3JAQ; EM; 6.00 A; b=1-82.
DR   PDB; 5IT7; EM; 3.60 A; b=1-82.
DR   PDB; 5IT9; EM; 3.80 A; b=1-82.
DR   PDB; 6FYX; EM; 3.05 A; b=1-82.
DR   PDB; 6FYY; EM; 3.05 A; b=1-82.
DR   PDB; 6GSM; EM; 5.15 A; b=2-82.
DR   PDB; 6GSN; EM; 5.75 A; b=2-82.
DR   PDB; 6UZ7; EM; 3.60 A; b=1-82.
DR   PDBsum; 3J80; -.
DR   PDBsum; 3J81; -.
DR   PDBsum; 3JAM; -.
DR   PDBsum; 3JAP; -.
DR   PDBsum; 3JAQ; -.
DR   PDBsum; 5IT7; -.
DR   PDBsum; 5IT9; -.
DR   PDBsum; 6FYX; -.
DR   PDBsum; 6FYY; -.
DR   PDBsum; 6GSM; -.
DR   PDBsum; 6GSN; -.
DR   PDBsum; 6UZ7; -.
DR   SMR; Q6CNL2; -.
DR   STRING; 28985.XP_454477.1; -.
DR   EnsemblFungi; CAG99564; CAG99564; KLLA0_E11661g.
DR   GeneID; 2894566; -.
DR   KEGG; kla:KLLA0_E11661g; -.
DR   eggNOG; KOG1779; Eukaryota.
DR   HOGENOM; CLU_130128_3_0_1; -.
DR   InParanoid; Q6CNL2; -.
DR   OMA; VYSHANT; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_00371; Ribosomal_S27e; 1.
DR   InterPro; IPR000592; Ribosomal_S27e.
DR   InterPro; IPR011332; Ribosomal_zn-bd.
DR   PANTHER; PTHR11594; PTHR11594; 1.
DR   Pfam; PF01667; Ribosomal_S27e; 1.
DR   SUPFAM; SSF57829; SSF57829; 1.
DR   PROSITE; PS01168; RIBOSOMAL_S27E; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81};
KW   Metal-binding {ECO:0000256|RuleBase:RU000671};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW   Ribonucleoprotein {ECO:0000256|RuleBase:RU000671};
KW   Ribosomal protein {ECO:0000256|RuleBase:RU000671};
KW   Zinc {ECO:0000256|RuleBase:RU000671};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000671}.
SQ   SEQUENCE   82 AA;  8869 MW;  B8A8153972CFB275 CRC64;
     MVLVQDLLHP TAASEARKHK LKTLVQSPRS HFLDVKCPGC LNITTVFSHA QTAVTCESCS
     TVLCTPTGGK AKLSEGTSFR RK
//
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