ID   Q6CR54_KLULA            Unreviewed;       793 AA.
AC   Q6CR54;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   24-JAN-2024, entry version 90.
DE   RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN   ORFNames=KLLA0_D11748g {ECO:0000313|EMBL:CAH00681.1};
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH00681.1, ECO:0000313|Proteomes:UP000000598};
RN   [1] {ECO:0000313|EMBL:CAH00681.1, ECO:0000313|Proteomes:UP000000598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37 {ECO:0000313|Proteomes:UP000000598};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA   Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA   Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC       biogenesis, stability and to maintain vacuole morphology.
CC       {ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- SIMILARITY: Belongs to the VPS16 family.
CC       {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR   EMBL; CR382124; CAH00681.1; -; Genomic_DNA.
DR   RefSeq; XP_453585.1; XM_453585.1.
DR   AlphaFoldDB; Q6CR54; -.
DR   STRING; 284590.Q6CR54; -.
DR   PaxDb; 284590-Q6CR54; -.
DR   GeneID; 2893232; -.
DR   KEGG; kla:KLLA0_D11748g; -.
DR   eggNOG; KOG2280; Eukaryota.
DR   HOGENOM; CLU_008909_1_0_1; -.
DR   InParanoid; Q6CR54; -.
DR   OMA; YVTFWYP; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR   Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR   InterPro; IPR016534; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR038132; Vps16_C_sf.
DR   InterPro; IPR006926; Vps16_N.
DR   PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR   PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
DR   PIRSF; PIRSF007949; VPS16; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW   Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT   DOMAIN          74..372
FT                   /note="Vps16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04841"
FT   DOMAIN          472..789
FT                   /note="Vps16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04840"
SQ   SEQUENCE   793 AA;  90874 MW;  15E3CAD22240F0D1 CRC64;
     MDLNPSLNWE RLQSLFYRSQ TLQSIGRKPS ATGLSVYLVA EPEKTFVYNY TDELQLTLNH
     EALPSAHLKS VIEDDQLVVI MKDRVRVYLS LITEEFKEHN ILDKERQPLS IWDYKDGIVI
     TTDFRIYRIY HQEQLFPNLA FSLLLKDHWF TNKSQIVLLD SSGTVIIGNI LSKELRQFEG
     WTGWYKGSIS ENGFVCLVNA KLNNLIVFDD DLNKPLIEVK LDELPKNIAW CANDLICCNF
     GDDEVRLIGS EKDYVSFWLP SHIVGLQSVS DGLKVITEDH IEFVSKVATY TSDIFSIGST
     APGAILLDSL NLLQNDENSP KAIENLKIIN LKKAVDECVS AAGDEINSIW QKRLLSAASF
     GKDSLSSTEF NASQFVITCN YLRVLNFLKT VGIFLTLRQF ISIGVEAIVL KLVNIRKIYE
     SYQIIDHLKC PELIPVVFNE WSKGKILTSP DSGNEALYQV VHDRALALNV QLQLSKVANI
     AFLDGRHSLA RKLALDDQNL LPKVDILLKM DEVNIATDEA NKSMDIPVVL FLLLYSKRVM
     STAQFTKNLI VTMKDNNVYQ FFQRNDFPFL YDYFRQTDDY LSLARLIWKH GKEEGQESNS
     LLSQVSDLYG KFMTNADVKR DRTTIERAKK LFLYQTDLSN KYGINFHNQT CDETLSTLIK
     VGQRNEVKRM INEFKISERK FYFLKCSCLA KEHKLKELYS FSQEKKSPIG YLPFFKAVSK
     YANKKDAAIY VNMLSSLTYA EKLDMYLDCK AYHEAISLAS HERDAIGLKQ VLNRIPQNET
     QLRSLAMQQL HSL
//