ID Q6CRW8_KLULA Unreviewed; 687 AA.
AC Q6CRW8;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=KLLA0D05819p {ECO:0000313|EMBL:CAH00417.1};
GN ORFNames=KLLA0_D05819g {ECO:0000313|EMBL:CAH00417.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH00417.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH00417.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR382124; CAH00417.1; -; Genomic_DNA.
DR RefSeq; XP_453321.1; XM_453321.1.
DR AlphaFoldDB; Q6CRW8; -.
DR STRING; 284590.Q6CRW8; -.
DR PaxDb; 284590-Q6CRW8; -.
DR GeneID; 2893131; -.
DR KEGG; kla:KLLA0_D05819g; -.
DR eggNOG; ENOG502QQWB; Eukaryota.
DR HOGENOM; CLU_008201_1_0_1; -.
DR InParanoid; Q6CRW8; -.
DR OMA; WSQKQPE; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50168; DED; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT DOMAIN 2..427
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 224..292
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 461..673
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 545..636
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
SQ SEQUENCE 687 AA; 79408 MW; 394411C32327E152 CRC64;
MPSFAESFWS PDFISGIEAL FGKLHKGCDQ NDLFIQLFAS RMQYEVEFGR HLCNINKGVD
EFDALDSTCN SSLAGMIGQM VEEGNHHLKI ASTIEMTVLG PFTKWRQEHK QRVQYSEKIL
KTNARSFLKS KGFVEKLEQT YLNKCRLLED FKRSTFNEDE LSDAMKSLDL QREHEAKVLQ
EKEYQKFGVF GGIDYDYKGI KETLKLLLTK LPKHQYKVPF ISFTIENTNS GSEIVAFLMT
HMSLKDIDHA ELFGQDLLNH GFIKYCNGVG TTFANSKKFQ YQWKPYAYKF CNLSTTDAND
DSLNEAESGI VNYFQKMTAG NEATYSSIHQ PNFSDNEKKL YKFVRDVEVS DSKYMKECKK
LDSLRCSFEE LIVDHYTFME KCESDRLMAI RKVTLDFCAA IGNTISSMKL TIEKLTDSEA
LIDPAADLLK TIEENRVGFF QPRVIPYNNY YNPGSYQTFG IDLETRCRSD NRLVPLILSA
ILLYMDQAYP EMENDYKRAI VWTKPVKLHE VHQLRQLLIK PFKEESEIIE ILRSKKVEPS
TVASVFKIYL LELPKSLITE DAYDILKVLY REYPPSDIKE ETENQRVRGL TTALSTLSKS
NMVTLDVITT HFERLIEIIR MNKSEESQEL AENLRDAISQ EFANCLIHPI LPTANELGYK
VFEDLLRHRK KIFKELKRKG SNPSSRG
//
