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Database: UniProt
Entry: Q6CTN7
LinkDB: Q6CTN7
Original site: Q6CTN7 
ID   MAK5_KLULA              Reviewed;         796 AA.
AC   Q6CTN7;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   16-OCT-2019, entry version 97.
DE   RecName: Full=ATP-dependent RNA helicase MAK5;
DE            EC=3.6.4.13;
GN   Name=MAK5; OrderedLocusNames=KLLA0C11253g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
OS   1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX24/MAK5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR382123; CAH01553.1; -; Genomic_DNA.
DR   RefSeq; XP_452702.1; XM_452702.1.
DR   SMR; Q6CTN7; -.
DR   STRING; 28985.XP_452702.1; -.
DR   PRIDE; Q6CTN7; -.
DR   EnsemblFungi; CAH01553; CAH01553; KLLA0_C11253g.
DR   GeneID; 2891940; -.
DR   KEGG; kla:KLLA0_C11253g; -.
DR   eggNOG; KOG0347; Eukaryota.
DR   eggNOG; ENOG410XS03; LUCA.
DR   HOGENOM; HOG000290702; -.
DR   InParanoid; Q6CTN7; -.
DR   KO; K14805; -.
DR   OMA; TMILASE; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    796       ATP-dependent RNA helicase MAK5.
FT                                /FTId=PRO_0000232237.
FT   DOMAIN      250    446       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      501    653       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     263    270       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       219    247       Q motif.
FT   MOTIF       379    382       DEAD box.
FT   COMPBIAS      7     43       Lys-rich.
FT   COMPBIAS    104    183       Glu-rich.
SQ   SEQUENCE   796 AA;  90131 MW;  DF44B968D091718C CRC64;
     MVYGVSKMAN KNRKNLKPVK SDRKDRISKN HSKKKVNKNS LKKVATTDIT VNANELNWKS
     VDIPDTLDDF GGFYGLEEID GVDVKVVDGK VQFITKDNKN VKKEPEQVEE KDNIVFQEDD
     EDVNMDELIE FKNFDDIKEG ELSAASDDEE SEFHVSTEEE GEEGEEAEDQ EEERSEKENV
     KGEAGTVVTE DQTNDDLLQS NVFSSNVDID DQEPPVLPEW SENMDLSFTV LKGLSGLGFT
     RPTEIQLKSI PLALKGHNIM GKASTGSGKT LAYGIPIIEQ LIKDTSNDRS IGLIFTPTRE
     LAHQVTDHLQ KVWTKMNKLN KYTILSLTGG LSIQKQERIL KYDGSGRIIV ATPGRFLELL
     ERNPDLIPRF AKIDTLVLDE ADRLLQDGHF DEFEKILKLL GKARKIKTSI DGKPTGSGWQ
     TMIFSATFSL DLFTKLDKTS WKILKTAGGE NNEMEQVLNH LMKKIQFKSK PVIIDTNPEH
     KVTSQVKESL IECLPMERDL YVYYFIMMYP GTTLVFCNAI DSVKKLNAFL NNLKISSFQI
     HSSMAQKNRL RNLEKFKEQS EKNSKVGKPT ILIASDVAAR GLDISGIKHV LHYHLPRSAD
     VYIHRSGRTA RGDNEGVSVM ICSPQESMGP LRKLRKVLST KKSSNPRKTK WQNDVPMLPL
     EPDIVSQLRE RSKIASELAD DEIATKSLHK DDNWLKKAAE ELDIELDSEE EEKDQFLARN
     KTKKLNKQLE KNENKALKYQ LNELLKMPLR KDLRKSYLTG GLTNLADTLV KHKGHNSIIG
     HDKVDALQTL KGKKHK
//
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