ID Q6CUK6_KLULA Unreviewed; 692 AA.
AC Q6CUK6;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=KLLA0C04169p {ECO:0000313|EMBL:CAH01234.1};
GN ORFNames=KLLA0_C04169g {ECO:0000313|EMBL:CAH01234.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01234.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01234.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; CR382123; CAH01234.1; -; Genomic_DNA.
DR RefSeq; XP_452383.1; XM_452383.1.
DR AlphaFoldDB; Q6CUK6; -.
DR STRING; 284590.Q6CUK6; -.
DR PaxDb; 284590-Q6CUK6; -.
DR GeneID; 2892029; -.
DR KEGG; kla:KLLA0_C04169g; -.
DR eggNOG; KOG3719; Eukaryota.
DR HOGENOM; CLU_013513_4_0_1; -.
DR InParanoid; Q6CUK6; -.
DR OMA; HILVMRR; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF29; MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 15..647
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 358
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 692 AA; 79703 MW; C86B7182D7936E87 CRC64;
MPSIKDTNQE VLPRLPIPPL EDTLKRYLAR LEPLQDSRSY EKTKRAVAES EQSLRIIDHE
LRKYDEHLAQ REPMSSYIEQ FWFDSYLEYD ESVVLNLNPY FQLADDPTMN NVPKVSSRFS
HFNRQVKRTS KLVVSMLKFV KAIRTGTLPT DNVRGKSMTM DQYGKLFGSS RLPPSLNDST
LSSCHLQTDP TSHHVVIMYK SQFYWFDVLD INNEPIFQQP EELEWNLYSI IMDSEQNSLD
QNLQNSCPMG VFTTENRRVW SNVRDYISKS EDQTNWRNLK IIDSALFIIC LDDSDLEGER
DWIKSMICGT SKIDLNDKDE DKTKPSLGLQ TGTCTNRWYD KLQLIVDRGG RAGINFEHTG
VDGHTVLRMT MDIYTDSIVN FAQGITRNVP KVFEDDDDDR RANRSTKQAN LITIPRKLEW
SVDSFILSSM HFAETRASDL ISQIEFEYLD FKQFGAAHIK NQFKCSPDAF LQMCFQTAYY
ALYGKFETTY EPAMTKFFQN GRTEAIRTVS DQSKSFVKSF FNTAVSNPDK IKLLQEACKQ
HSNVTRECSM GLGQDRHLYA LYCIWKKVFA KDPKVPLPQL FQDAGWSTLN TNVISTSNCG
NPCLKNFGFG PVCSNGFGIG YIIRNDTLSV VVSSRHRQTA RFVELMQRFL LEINRIVRNE
EQSSKTSMGS LQSDNMKYLL SGYDYFDVSV TG
//
