ID Q6CUS2_KLULA Unreviewed; 686 AA.
AC Q6CUS2;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=KLLA0C02695p {ECO:0000313|EMBL:CAH01168.1};
GN ORFNames=KLLA0_C02695g {ECO:0000313|EMBL:CAH01168.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01168.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01168.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2] {ECO:0007829|PDB:3K8P}
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 332-686.
RX PubMed=20005805; DOI=10.1016/j.cell.2009.11.002;
RA Ren Y., Yip C.K., Tripathi A., Huie D., Jeffrey P.D., Walz T.,
RA Hughson F.M.;
RT "A structure-based mechanism for vesicle capture by the multisubunit
RT tethering complex Dsl1.";
RL Cell 139:1119-1129(2009).
RN [3] {ECO:0007829|PDB:8FTU}
RP X-RAY CRYSTALLOGRAPHY (5.73 ANGSTROMS) OF 332-366 AND 424-686.
RX DOI=10.1101/2023.01.30.526244;
RA DAmico K.A., Stanton A.E., Shirkey J.D., Travis S.M., Jeffrey P.D.,
RA Hughson F.M.;
RT "Structure of a Membrane Tethering Complex Incorporating Multiple SNAREs.";
RL bioRxiv 0:0-0(2023).
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DR EMBL; CR382123; CAH01168.1; -; Genomic_DNA.
DR RefSeq; XP_452317.1; XM_452317.1.
DR PDB; 3K8P; X-ray; 2.60 A; C=332-686.
DR PDB; 8FTU; X-ray; 5.73 A; C=332-366, C=424-686.
DR PDBsum; 3K8P; -.
DR AlphaFoldDB; Q6CUS2; -.
DR SMR; Q6CUS2; -.
DR IntAct; Q6CUS2; 1.
DR STRING; 284590.Q6CUS2; -.
DR PaxDb; 284590-Q6CUS2; -.
DR GeneID; 2891911; -.
DR KEGG; kla:KLLA0_C02695g; -.
DR eggNOG; ENOG502QR7Q; Eukaryota.
DR HOGENOM; CLU_357169_0_0_1; -.
DR InParanoid; Q6CUS2; -.
DR OMA; NHLKDIM; -.
DR EvolutionaryTrace; Q6CUS2; -.
DR Proteomes; UP000000598; Chromosome C.
DR Gene3D; 1.10.287.3290; -; 1.
DR Gene3D; 1.10.357.150; -; 1.
DR Gene3D; 1.20.58.1440; -; 2.
DR Gene3D; 1.20.58.2230; Retrograde transport protein Dsl1, N-terminal domain; 1.
DR InterPro; IPR021876; Dsl1_C.
DR InterPro; IPR021875; Dsl1_N_dom.
DR InterPro; IPR038442; Dsl1_N_sf.
DR InterPro; IPR046362; Zw10/DSL1_C_sf.
DR PANTHER; PTHR12205; CENTROMERE/KINETOCHORE PROTEIN ZW10; 1.
DR PANTHER; PTHR12205:SF0; CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG; 1.
DR Pfam; PF11989; Dsl1_C; 1.
DR Pfam; PF11988; Dsl1_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3K8P, ECO:0007829|PDB:8FTU};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT DOMAIN 12..352
FT /note="Retrograde transport protein Dsl1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11988"
FT DOMAIN 496..686
FT /note="Retrograde transport protein Dsl1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11989"
FT REGION 374..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 80521 MW; 0D094B3F20EB033B CRC64;
MATLEKLLND LLSDTSALSQ AIEADPQFKS SDSVHPKPNS KLLEEVLRED SDLTKDLAKY
NQYKILSDLL KEFNTNYELN ELENCYYSLQ NIHKKFKDVN ISGESFRFQQ SVATYIDCLH
LNVLERFKEV SNMFYTISGN EMMFKKTIEL DSVEFNFDEM VELFENNFFD HNMIDQTHWF
IASTNLETYK DKEIVLLQEI LDDTVKLNPL IKFFKEFVFD EKCIMVRAEP GKLTLATSEY
NSLDQIKSYQ TLTTFIENDL SKHAKESVMI HFGNVLLTEL LKIIRANPEL LSNDKEQTTE
IISSIHDSLT KISEETEWAY DGFELNRILK DENIYTTLKF ESMMQQRVIQ IRSIPEEEYH
ELVSVQFKTD GGKYEKGEKQ DLELSEKKTE NGKDTESWGW NENQDSDEHD GWDEELDIDV
DNVPIQVSVF VQSAAKVFTE FEQGCDTIGR SKVESIYLYK FNLLQTAFFA MVSEKVNDWT
QLYKDVRYLY TENPKLLQLM ELNSRRLDLN LNLIKKTIYK LVNDQLQELK DNERTPDWDI
TISSLLPYLK KTALPTLYKL EDNTILVALI RYIVHDLVID NILHWRVISE KSSENLSEFI
MLLLSGLEIP RLNLIETYRH SREKLGILSK ILTAHLKDIL EMFYEGEFFL FETDEIVQWI
ILLFADTPTR RDCIDEIRRV REEATD
//