ID Q6CUS6_KLULA Unreviewed; 473 AA.
AC Q6CUS6;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=KLLA0C02607p {ECO:0000313|EMBL:CAH01164.1};
GN ORFNames=KLLA0_C02607g {ECO:0000313|EMBL:CAH01164.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01164.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01164.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC5 family.
CC {ECO:0000256|ARBA:ARBA00006269}.
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DR EMBL; CR382123; CAH01164.1; -; Genomic_DNA.
DR RefSeq; XP_452313.1; XM_452313.1.
DR AlphaFoldDB; Q6CUS6; -.
DR STRING; 284590.Q6CUS6; -.
DR PaxDb; 284590-Q6CUS6; -.
DR GeneID; 2892429; -.
DR KEGG; kla:KLLA0_C02607g; -.
DR eggNOG; KOG2543; Eukaryota.
DR HOGENOM; CLU_028223_2_1_1; -.
DR InParanoid; Q6CUS6; -.
DR OMA; AYICSYL; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR020796; ORC5.
DR InterPro; IPR047088; ORC5_C.
DR InterPro; IPR048866; ORC5_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12705; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12705:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14630; ORC5_C; 1.
DR Pfam; PF21639; ORC5_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT DOMAIN 7..151
FT /note="Orc1-like AAA ATPase"
FT /evidence="ECO:0000259|Pfam:PF13191"
FT DOMAIN 232..287
FT /note="ORC5 lid"
FT /evidence="ECO:0000259|Pfam:PF21639"
FT DOMAIN 319..468
FT /note="Origin recognition complex subunit 5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14630"
SQ SEQUENCE 473 AA; 54571 MW; 8392A24819BB4135 CRC64;
MVRPDVRYRE EQLDFLEAFV DADPKLSPPI LFIEGPHGSG KTHTLKKFFA CNEEIMNILL
PAKDLIYSKS TCQRLATCLR QLLLKQFPSV ETTDLDPFEA EDVYLLQKFI NKLFIRFNHL
VERVNLYVIL DGLDDNSQVN LETPTQLMAL PGSILPQAMI QLRLIISFSK SSFLSNYSTF
KVPTIFFPKY KPLEIEYIVS QTPGFSDDPL LLEKMDEIGC GNTEQFRSEI FEKYIHFLIE
SLIVYTGYDP TALIDIMRIK WRCFVRSLNQ ENIKNTVQLY KSNLELFNKP NERLIPQTSR
SDQNSLSGTG SVGYSSHSLC FMAKYLLIAA YLASYLNHRY DSKVFSKKSH LRGGRSSYGR
RSKPANNPRY LQPSGFSLER MLAIFQSIYP VRVSKELSPD FFQRDVHMKA NVEVYENVSE
LITSQLLTGL NMHKLGYLHE RLKFKVNVTW DYILLVAGSV DFDISEYFSD VVE
//
