UniProt: Q6CVZ5

Database: UniProt
Entry: Q6CVZ5

LinkDB:  Q6CVZ5 
Original site:  Q6CVZ5

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Ontology (1)   
   GO (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
3D Structure (12)   
   PDB (12)   
Protein domain (5)   
   InterPro (4)   
   Pfam (1)   
Literature (7)   
   PubMed (7)   
All databases (29)   

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ID   Q6CVZ5_KLULA            Unreviewed;       106 AA.
AC   Q6CVZ5;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   SubName: Full=KLLA0B08173p {ECO:0000313|EMBL:CAH02287.1};
GN   ORFNames=KLLA0_B08173g {ECO:0000313|EMBL:CAH02287.1};
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH02287.1, ECO:0000313|Proteomes:UP000000598};
RN   [1] {ECO:0000313|EMBL:CAH02287.1, ECO:0000313|Proteomes:UP000000598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37 {ECO:0000313|Proteomes:UP000000598};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA   Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA   Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2] {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS).
RX   PubMed=25417110; DOI=10.1016/j.cell.2014.10.001;
RA   Hussain T., Llacer J.L., Fernandez I.S., Munoz A., Martin-Marcos P.,
RA   Savva C.G., Lorsch J.R., Hinnebusch A.G., Ramakrishnan V.;
RT   "Structural changes enable start codon recognition by the eukaryotic
RT   translation initiation complex.";
RL   Cell 159:597-607(2014).
RN   [3] {ECO:0007829|PDB:3JAM, ECO:0007829|PDB:3JAP}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS).
RX   PubMed=26212456; DOI=10.1016/j.molcel.2015.06.033;
RA   Llacer J.L., Hussain T., Marler L., Aitken C.E., Thakur A., Lorsch J.R.,
RA   Hinnebusch A.G., Ramakrishnan V.;
RT   "Conformational differences between open and closed states of the
RT   eukaryotic translation initiation complex.";
RL   Mol. Cell 59:399-412(2015).
RN   [4] {ECO:0007829|PDB:5IT7, ECO:0007829|PDB:5IT9}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) OF 1-96.
RX   PubMed=27159451; DOI=10.7554/eLife.13567;
RA   Murray J., Savva C.G., Shin B.S., Dever T.E., Ramakrishnan V.,
RA   Fernandez I.S.;
RT   "Structural characterization of ribosome recruitment and translocation by
RT   type IV IRES. .";
RL   Elife 5:e13567-e13567(2016).
RN   [5] {ECO:0007829|PDB:6FYX, ECO:0007829|PDB:6FYY}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.05 ANGSTROMS).
RX   PubMed=30475211; DOI=10.7554/eLife.39273;
RA   Llacer J.L., Hussain T., Saini A.K., Nanda J.S., Kaur S., Gordiyenko Y.,
RA   Kumar R., Hinnebusch A.G., Lorsch J.R., Ramakrishnan V.;
RT   "Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal
RT   subunit to promote start-codon recognition.";
RL   Elife 7:e39273-e39273(2018).
RN   [6] {ECO:0007829|PDB:6UZ7}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX   PubMed=31900355; DOI=10.1073/pnas.1916436117;
RA   Huang B.Y., Fernandez I.S.;
RT   "Long-range interdomain communications in eIF5B regulate GTP hydrolysis and
RT   translation initiation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:1429-1437(2020).
RN   [7] {ECO:0007829|PDB:6GSM, ECO:0007829|PDB:6GSN}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.15 ANGSTROMS) OF 1-96.
RX   PubMed=34648019; DOI=10.1093/nar/gkab908;
RA   Llacer J.L., Hussain T., Dong J., Villamayor L., Gordiyenko Y.,
RA   Hinnebusch A.G.;
RT   "Large-scale movement of eIF3 domains during translation initiation
RT   modulate start codon selection.";
RL   Nucleic Acids Res. 49:11491-11511(2021).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS10 family.
CC       {ECO:0000256|ARBA:ARBA00007278}.
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DR   EMBL; CR382122; CAH02287.1; -; Genomic_DNA.
DR   RefSeq; XP_451894.1; XM_451894.1.
DR   PDB; 3J80; EM; 3.75 A; K=1-106.
DR   PDB; 3J81; EM; 4.00 A; K=1-106.
DR   PDB; 3JAM; EM; 3.46 A; K=1-106.
DR   PDB; 3JAP; EM; 4.90 A; K=1-106.
DR   PDB; 5IT7; EM; 3.60 A; K=1-96.
DR   PDB; 5IT9; EM; 3.80 A; K=1-96.
DR   PDB; 6FYX; EM; 3.05 A; K=1-106.
DR   PDB; 6FYY; EM; 3.05 A; K=1-106.
DR   PDB; 6GSM; EM; 5.20 A; K=1-96.
DR   PDB; 6GSN; EM; 5.75 A; K=1-96.
DR   PDB; 6UZ7; EM; 3.60 A; K=1-106.
DR   PDBsum; 3J80; -.
DR   PDBsum; 3J81; -.
DR   PDBsum; 3JAM; -.
DR   PDBsum; 3JAP; -.
DR   PDBsum; 3JAQ; -.
DR   PDBsum; 5IT7; -.
DR   PDBsum; 5IT9; -.
DR   PDBsum; 6FYX; -.
DR   PDBsum; 6FYY; -.
DR   PDBsum; 6GSM; -.
DR   PDBsum; 6GSN; -.
DR   PDBsum; 6UZ7; -.
DR   AlphaFoldDB; Q6CVZ5; -.
DR   EMDB; EMD-0057; -.
DR   EMDB; EMD-0058; -.
DR   EMDB; EMD-20952; -.
DR   EMDB; EMD-4327; -.
DR   EMDB; EMD-4328; -.
DR   EMDB; EMD-8123; -.
DR   SMR; Q6CVZ5; -.
DR   STRING; 284590.Q6CVZ5; -.
DR   PaxDb; 284590-Q6CVZ5; -.
DR   GeneID; 2896964; -.
DR   KEGG; kla:KLLA0_B08173g; -.
DR   eggNOG; KOG3344; Eukaryota.
DR   HOGENOM; CLU_089349_4_1_1; -.
DR   InParanoid; Q6CVZ5; -.
DR   OMA; ERTKIHR; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005326; Plectin_eS10_N.
DR   InterPro; IPR037447; Ribosomal_eS10.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12146; 40S RIBOSOMAL PROTEIN S10; 1.
DR   PANTHER; PTHR12146:SF0; S10_PLECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03501; S10_plectin; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT   DOMAIN          3..92
FT                   /note="Plectin/eS10 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03501"
SQ   SEQUENCE   106 AA;  12566 MW;  D8C0A10ACEB0BB2D CRC64;
     MLIPKEDRKK IYQHLFQEGV LVAKKDFNQP KHEEIDTKNL FVIKALQSLT SKGFVKTQFS
     WQYYYYTLTE EGVVYLREYL NLPEHIFPAT YLAGQSGDQR PQGKKY
//

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