ID Q6CWT9_KLULA Unreviewed; 146 AA.
AC Q6CWT9;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=KLLA0B01562p {ECO:0000313|EMBL:CAH01993.1};
GN ORFNames=KLLA0_B01562g {ECO:0000313|EMBL:CAH01993.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01993.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH01993.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2] {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS).
RX PubMed=25417110; DOI=10.1016/j.cell.2014.10.001;
RA Hussain T., Llacer J.L., Fernandez I.S., Munoz A., Martin-Marcos P.,
RA Savva C.G., Lorsch J.R., Hinnebusch A.G., Ramakrishnan V.;
RT "Structural changes enable start codon recognition by the eukaryotic
RT translation initiation complex.";
RL Cell 159:597-607(2014).
RN [3] {ECO:0007829|PDB:3JAM, ECO:0007829|PDB:3JAP}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS).
RX PubMed=26212456; DOI=10.1016/j.molcel.2015.06.033;
RA Llacer J.L., Hussain T., Marler L., Aitken C.E., Thakur A., Lorsch J.R.,
RA Hinnebusch A.G., Ramakrishnan V.;
RT "Conformational differences between open and closed states of the
RT eukaryotic translation initiation complex.";
RL Mol. Cell 59:399-412(2015).
RN [4] {ECO:0007829|PDB:5IT7, ECO:0007829|PDB:5IT9}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) OF 2-146.
RX PubMed=27159451; DOI=10.7554/eLife.13567;
RA Murray J., Savva C.G., Shin B.S., Dever T.E., Ramakrishnan V.,
RA Fernandez I.S.;
RT "Structural characterization of ribosome recruitment and translocation by
RT type IV IRES. .";
RL Elife 5:e13567-e13567(2016).
RN [5] {ECO:0007829|PDB:6FYX, ECO:0007829|PDB:6FYY}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.05 ANGSTROMS).
RX PubMed=30475211; DOI=10.7554/eLife.39273;
RA Llacer J.L., Hussain T., Saini A.K., Nanda J.S., Kaur S., Gordiyenko Y.,
RA Kumar R., Hinnebusch A.G., Lorsch J.R., Ramakrishnan V.;
RT "Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal
RT subunit to promote start-codon recognition.";
RL Elife 7:e39273-e39273(2018).
RN [6] {ECO:0007829|PDB:6UZ7}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX PubMed=31900355; DOI=10.1073/pnas.1916436117;
RA Huang B.Y., Fernandez I.S.;
RT "Long-range interdomain communications in eIF5B regulate GTP hydrolysis and
RT translation initiation.";
RL Proc. Natl. Acad. Sci. U.S.A. 117:1429-1437(2020).
RN [7] {ECO:0007829|PDB:6GSM, ECO:0007829|PDB:6GSN}
RP STRUCTURE BY ELECTRON MICROSCOPY (5.15 ANGSTROMS) OF 2-146.
RX PubMed=34648019; DOI=10.1093/nar/gkab908;
RA Llacer J.L., Hussain T., Dong J., Villamayor L., Gordiyenko Y.,
RA Hinnebusch A.G.;
RT "Large-scale movement of eIF3 domains during translation initiation
RT modulate start codon selection.";
RL Nucleic Acids Res. 49:11491-11511(2021).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS13 family.
CC {ECO:0000256|ARBA:ARBA00008080, ECO:0000256|RuleBase:RU003830}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382122; CAH01993.1; -; Genomic_DNA.
DR RefSeq; XP_451600.1; XM_451600.1.
DR PDB; 3J80; EM; 3.75 A; S=1-146.
DR PDB; 3J81; EM; 4.00 A; S=1-146.
DR PDB; 3JAM; EM; 3.46 A; S=1-146.
DR PDB; 3JAP; EM; 4.90 A; S=1-146.
DR PDB; 5IT7; EM; 3.60 A; S=2-146.
DR PDB; 5IT9; EM; 3.80 A; S=2-146.
DR PDB; 6FYX; EM; 3.05 A; S=1-146.
DR PDB; 6FYY; EM; 3.05 A; S=1-146.
DR PDB; 6GSM; EM; 5.20 A; S=2-146.
DR PDB; 6GSN; EM; 5.75 A; S=2-146.
DR PDB; 6UZ7; EM; 3.60 A; S=1-146.
DR PDBsum; 3J80; -.
DR PDBsum; 3J81; -.
DR PDBsum; 3JAM; -.
DR PDBsum; 3JAP; -.
DR PDBsum; 3JAQ; -.
DR PDBsum; 5IT7; -.
DR PDBsum; 5IT9; -.
DR PDBsum; 6FYX; -.
DR PDBsum; 6FYY; -.
DR PDBsum; 6GSM; -.
DR PDBsum; 6GSN; -.
DR PDBsum; 6UZ7; -.
DR AlphaFoldDB; Q6CWT9; -.
DR EMDB; EMD-0057; -.
DR EMDB; EMD-0058; -.
DR EMDB; EMD-20952; -.
DR EMDB; EMD-4327; -.
DR EMDB; EMD-4328; -.
DR EMDB; EMD-8123; -.
DR SMR; Q6CWT9; -.
DR STRING; 284590.Q6CWT9; -.
DR PaxDb; 284590-Q6CWT9; -.
DR GeneID; 2897028; -.
DR KEGG; kla:KLLA0_B01562g; -.
DR eggNOG; KOG3311; Eukaryota.
DR HOGENOM; CLU_103849_0_1_1; -.
DR InParanoid; Q6CWT9; -.
DR OMA; SYKGVRH; -.
DR Proteomes; UP000000598; Chromosome B.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 1.10.8.50; -; 1.
DR Gene3D; 4.10.910.10; 30s ribosomal protein s13, domain 2; 1.
DR HAMAP; MF_01315; Ribosomal_S13_S18; 1.
DR InterPro; IPR027437; Rbsml_uS13_C.
DR InterPro; IPR001892; Ribosomal_uS13.
DR InterPro; IPR010979; Ribosomal_uS13-like_H2TH.
DR InterPro; IPR018269; Ribosomal_uS13_CS.
DR PANTHER; PTHR10871; 30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18; 1.
DR PANTHER; PTHR10871:SF3; 40S RIBOSOMAL PROTEIN S18; 1.
DR Pfam; PF00416; Ribosomal_S13; 1.
DR PIRSF; PIRSF002134; Ribosomal_S13; 1.
DR SUPFAM; SSF46946; S13-like H2TH domain; 1.
DR PROSITE; PS00646; RIBOSOMAL_S13_1; 1.
DR PROSITE; PS50159; RIBOSOMAL_S13_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU003830};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW ECO:0000256|RuleBase:RU003830}.
SQ SEQUENCE 146 AA; 17051 MW; 555EED5E06AD91A8 CRC64;
MSLVVQEQGS FQHILRLLNT NVDGNINVVY ALTTIRGVGR RYANLVCKKA DVDLHKRAGE
LTQEELERIV QIMQNPTHYK IPAWFLNRQK DVNDGKDYHS LANNLESKLR DDLERLKKIR
SHRGIRHFWG LRVRGQHTKT TGRRRA
//
