ID Q6CX26_KLULA Unreviewed; 1343 AA.
AC Q6CX26;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE SubName: Full=KLLA0A11792p {ECO:0000313|EMBL:CAH03101.1};
GN ORFNames=KLLA0_A11792g {ECO:0000313|EMBL:CAH03101.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH03101.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH03101.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR382121; CAH03101.1; -; Genomic_DNA.
DR RefSeq; XP_451513.1; XM_451513.1.
DR STRING; 284590.Q6CX26; -.
DR PaxDb; 284590-Q6CX26; -.
DR GeneID; 2896708; -.
DR KEGG; kla:KLLA0_A11792g; -.
DR eggNOG; KOG3687; Eukaryota.
DR HOGENOM; CLU_003828_0_0_1; -.
DR InParanoid; Q6CX26; -.
DR Proteomes; UP000000598; Chromosome A.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT DOMAIN 1105..1343
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
SQ SEQUENCE 1343 AA; 154283 MW; 65BD0BD160F40EB1 CRC64;
MINKVIICKQ REHKRVPEAA RHMSLSNSSH SSGSDSVRSS VFREFSLLLK RHNSDMKVRT
LEEHKEWLDH LDSEADAKHR RKAILNITDN IDKYEKSEIP LIWVKATSLL KRDVDNTESR
MLLELLSKCC LHCGNEHSVR LMFYFTLIDF CCVMGDKITL NRASLDSSLD LIFNGIDGLT
HQGTDIVIFE QHATMNISQL LSLSLSNILN FNTRTCISFL SFLNNCLRNS TLTVDGLGMI
IHCAQKTPSP EVLLCCFHTI NILISTEHED ISDQSTYDLA YLITGAINLD NKFNQQLLKT
LDALIESKYW DQFAYQLKIL MESPDTNYLN LRGAVTILTD FALQDKEDWF VWLTKIFERG
NTMYGQILEC IKTLITDDHF CEQGNGYVWY NEENMCLLKM LREILSVDVI RDNNPITIAS
IYNALFQALL SKKWELYGLK NSSDLLALVI EHEELLSKEQ ISIIAQYLES YRDPFPQSSL
TKILHMLDAT DERTAAIVKY FANSYALFDS ACKKLIEKSV LELLSCDESQ SVFVSCTEFL
VVLSEYIPTD ALKSYVEAYL VPKQPRRKSI VSIGIDPHKI KWKLTEQSIA LVRLFQRKIF
MFPYLILTWR CCIKAKDTVA LLVLARILMK MRIDADSLFY FCEETDIDGL TATLNRNTVI
KPEGIDGSYL WKYPEDETTS YIDKGTLGKK FDADCLAYID ISEWTELLIE TLRKPLDWEL
YTYLLSHLCP QLANYHLFKN DRHNIEILHD LILHQLKDGC PIKMGVGINK SDVQLAFVRT
LSSLFPYYGF LGKSKADEMI KISLGVLESS FEKTIVPLLH NFSVSCYEIP SSIKKHLNPL
LETISIRLTK KQAIPCLLEF LIALSDSPQI ISPLTIDQLK RVFTIAFKLI EVSHDLKEEA
EEADFVRHSF TDEQEASFNP STSSFTVTKQ MAHFYLTLSY QIISHWFIRI SLSKRPLIAP
FLMVKLSTLK RCDDTEAYKD LVTRFTTTDL ELRVETVTSD TPNSGDPHYL HEYWYRDGKI
LSIEVNTTTG ASLVVTRGAS GNSIFNVDPI VKKEPDSFDL FQFGKNTKPA SANMFTPGYV
LAQFSAEDTY EDMVRIEEPH LIKSIQLVDT IPVVEFHKIG LLYMGPNDTT EKDILSHSME
DGSHQYKWFV NELGSIIKLD QNETFYIGGL NPGTDGEYAL IWHDQKCQIV FHTVSLMPND
DKADPDRTMK KRHVGNNFIN IYYDERKQDS FPFDIIKSQF NFINLVIKPM WNGKDEKDSV
SEFYKVKIYR AKEVPGIFST SHFKIMHRQR LAAYVRHLCT VANTFAQIWH ESVSSEHCST
WSRRFAHIKT IKTRLKNQSS GAS
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