ID Q6CXU8_KLULA Unreviewed; 759 AA.
AC Q6CXU8;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
GN ORFNames=KLLA0_A05456g {ECO:0000313|EMBL:CAH02829.1};
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH02829.1, ECO:0000313|Proteomes:UP000000598};
RN [1] {ECO:0000313|EMBL:CAH02829.1, ECO:0000313|Proteomes:UP000000598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC WM37 {ECO:0000313|Proteomes:UP000000598};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000256|RuleBase:RU365057}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU365057}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC ECO:0000256|RuleBase:RU365057}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382121; CAH02829.1; -; Genomic_DNA.
DR RefSeq; XP_451241.1; XM_451241.1.
DR AlphaFoldDB; Q6CXU8; -.
DR STRING; 284590.Q6CXU8; -.
DR PaxDb; 284590-Q6CXU8; -.
DR GeneID; 2896334; -.
DR KEGG; kla:KLLA0_A05456g; -.
DR eggNOG; KOG2229; Eukaryota.
DR HOGENOM; CLU_009161_2_1_1; -.
DR InParanoid; Q6CXU8; -.
DR OMA; AMYKTYK; -.
DR Proteomes; UP000000598; Chromosome A.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:UniProtKB-UniRule.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR048292; SDA1_C.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF21638; SDA1_C; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365057};
KW Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU365057};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT DOMAIN 70..449
FT /note="SDA1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08158"
FT DOMAIN 553..691
FT /note="SDA1 middle"
FT /evidence="ECO:0000259|Pfam:PF05285"
FT DOMAIN 711..757
FT /note="SDA1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21638"
FT REGION 475..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..612
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..736
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 86489 MW; 46227A69FE8601D1 CRC64;
MVRRSRAAIL PTNIILLQNL VKRDPESYRE EFLQQYAHYQ SLRDIFMLNS VNNESTDESA
MAEFMGAIGF VSQVCSCYPR ETANFPNELK QLVLDHHKSL PFDVKEKIIT SLTMLRNKNV
ISPETLIQTM FPLLIAYSSP SNSMVQNSHA KELRTLIYNT LVQLMKSCNT SGKNQKLNKS
THALCFNLLE QPDSQGIWAS KLTRELWRRG IWDDSRSVEI MTHAALHNDV KIAYSGVLFF
LDADKEREEA FEENDDEDEI DTTALKHKLQ INKKSSKRGK KLEQALKVVK KKSAKGVQQN
NFLNFSAIHL LRDPQGFAEK LFERHLSGKN SNKFDFEQKT AIMQLLSRLT GTHKLMVLGL
YSYFLKYLTP KQRDVTKILS AAAQSCHDLV PPETIEVMVR KIANEFVSDG VSNEVATVGL
NTVREILTRA PLAIDETLLQ DLTEYKGSKA KSVAIAAKGL IALYREVAPE MLKKKDRGKT
ASMGLQDDKR NGRESKRVKF GVETTNVQGI DGIELLAKWK RENGNEEDDD DEAAWDLNNR
DELSDASDVE GEWVTIESDK EYEVDMDSDD EESKNKTGHK GKKRSHDEVE PEAGEDSDLE
LSGDEEEPKV GEEQKEESES ADPEEAFREL ASSRILTPAD FAKLQELRTE KGVTKLMGIN
NEETIEHYKL MGPAKHKKQN KEERMASIME GREDREKYGS KRGKRDSSMR STTNKEKSRK
KNFVMMIHKR SVKGKQKMSL RDKQKVLRAH ITKQKKKGN
//
