ID Q6D515_PECAS Unreviewed; 611 AA.
AC Q6D515;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:CAG75128.1};
GN OrderedLocusNames=ECA2226 {ECO:0000313|EMBL:CAG75128.1};
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491 {ECO:0000313|EMBL:CAG75128.1, ECO:0000313|Proteomes:UP000007966};
RN [1] {ECO:0000313|EMBL:CAG75128.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SCRI1043 {ECO:0000313|EMBL:CAG75128.1};
RA Bell K.S., Sebaihia M., Pritchard L., Holden M., Hyman L.J., Holeva M.C.,
RA Thomson N.R., Bentley S.D., Churcher C., Mungall K., Atkin R., Bason N.,
RA Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z.,
RA Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C.,
RA Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C.,
RA Birch P.R.J., Barrell B.G., Parkhill J., Toth I.K.;
RT "The genome sequence of the enterobacterial phytopathogen Erwinia
RT carotovora subsp. atroseptica SCRI1043 and functional genomic
RT identification of novel virulence factors.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:7PSG}
RP X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 2-271 IN COMPLEX WITH GLYCINE
RP BETAINE.
RX PubMed=35254130; DOI=10.1128/mbio.03458-21;
RA Matilla M.A., Velando F., Tajuelo A., Martin-Mora D., Xu W., Sourjik V.,
RA Gavira J.A., Krell T.;
RT "Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the
RT Neurotransmitter Acetylcholine.";
RL MBio 13:e0345821-e0345821(2022).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX950851; CAG75128.1; -; Genomic_DNA.
DR PDB; 7PSG; X-ray; 1.91 A; A/B/C/D=2-271.
DR AlphaFoldDB; Q6D515; -.
DR SMR; Q6D515; -.
DR STRING; 218491.ECA2226; -.
DR KEGG; eca:ECA2226; -.
DR eggNOG; COG0840; Bacteria.
DR HOGENOM; CLU_000445_107_12_6; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd11386; MCP_signal; 1.
DR CDD; cd12913; PDC1_MCP_like; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR004089; MCPsignal_dom.
DR PANTHER; PTHR43531:SF14; METHYL-ACCEPTING CHEMOTAXIS PROTEIN I-RELATED; 1.
DR PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00283; MA; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7PSG};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007966};
KW Transducer {ECO:0000256|PROSITE-ProRule:PRU00284};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 355..584
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000259|PROSITE:PS50111"
FT BINDING 113
FT /ligand="glycine betaine"
FT /ligand_id="ChEBI:CHEBI:17750"
FT /evidence="ECO:0007829|PDB:7PSG"
FT BINDING 119
FT /ligand="glycine betaine"
FT /ligand_id="ChEBI:CHEBI:17750"
FT /evidence="ECO:0007829|PDB:7PSG"
SQ SEQUENCE 611 AA; 65901 MW; 0092973E50CE0B3E CRC64;
MAERYLQQIA QSEALRIQQE LNYARDVAHN LGQGLAALPS AGIKDRAVVD KMMEYALRDN
PEYLSISVIF EENVFDGRDA EFADQPGQAP KGRYAWFVDR DQAGNYAMHP LLSYLTPGQG
DYYLLPQKSQ KDTLIEPYTY AYNGVPTLLT SVAAPIVSQG KLWGVVTSDI SLASLQQKIN
QIKPWEGGGY AMLLSSAGKV ISYPDKSQTS KAWQGPTDNF TSSVVQHDDA ILGEQALVTW
QPVTIGNSTE KWYLGIVVPV SQVMAASERQ LINAVIMMVI SILLVSALLG WVFSRKVLKP
IGGEPLEAAT IALSVAEGRL SNVIDVKAND RSSLFFALNT MQSQLRQVVG QIKDASDSVR
QGAAEIASGN LNLASRTEQQ AAALEQTAAS MEEITATVKH NANNAHQATT LTENATKIAL
RGESLVSQVV QTMSQIDDSA KKIGDITSMI NSIAFQTNIL ALNAAVEAAR AGEQGRGFAV
VASEVRSLAQ RSASAVKEIA ALIEESSQRV ESGVKLVNDA GKTMQDMTHA VNSVQSIIGE
IVTASDEQAK GISQVTIAVN EMDGVTQQNS ALVQQMSAAA SSLEDQSMLL AQTIEHFRLE
QQHALPHALL R
//
