ID Q6D7S5_PECAS Unreviewed; 716 AA.
AC Q6D7S5;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Formate dehydrogenase H {ECO:0000313|EMBL:CAG74160.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:CAG74160.1};
GN Name=fdhF {ECO:0000313|EMBL:CAG74160.1};
GN OrderedLocusNames=ECA1250 {ECO:0000313|EMBL:CAG74160.1};
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491 {ECO:0000313|EMBL:CAG74160.1, ECO:0000313|Proteomes:UP000007966};
RN [1] {ECO:0000313|EMBL:CAG74160.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SCRI1043 {ECO:0000313|EMBL:CAG74160.1};
RA Bell K.S., Sebaihia M., Pritchard L., Holden M., Hyman L.J., Holeva M.C.,
RA Thomson N.R., Bentley S.D., Churcher C., Mungall K., Atkin R., Bason N.,
RA Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z.,
RA Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C.,
RA Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C.,
RA Birch P.R.J., Barrell B.G., Parkhill J., Toth I.K.;
RT "The genome sequence of the enterobacterial phytopathogen Erwinia
RT carotovora subsp. atroseptica SCRI1043 and functional genomic
RT identification of novel virulence factors.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; BX950851; CAG74160.1; -; Genomic_DNA.
DR RefSeq; WP_011092840.1; NC_004547.2.
DR AlphaFoldDB; Q6D7S5; -.
DR SMR; Q6D7S5; -.
DR STRING; 218491.ECA1250; -.
DR KEGG; eca:ECA1250; -.
DR PATRIC; fig|218491.5.peg.1271; -.
DR eggNOG; COG3383; Bacteria.
DR HOGENOM; CLU_000422_4_0_6; -.
DR OrthoDB; 9810782at2; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:1990204; C:oxidoreductase complex; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0045333; P:cellular respiration; IEA:UniProt.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR PIRSF; PIRSF000144; CbbBc; 2.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CAG74160.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007966}.
FT DOMAIN 1..56
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 716 AA; 79399 MW; 1CF78E9A231C9EFC CRC64;
MKKITSVCPY CGAGCKLKLV VEDNKIIRAE AADGVTNQNE LCLKGYYGWD FLNDTQLLTP
RLTQPMIRYE KGGRLTPVSW DEAIRYTAQR FSEIKAKYGP RSIMTTGSSR GTGNETNYVM
QKFARAVLNT NNVDCCARVC HGPSVAGLQE VLGNGAMSNS ISDIENSKCL LIFGYNSADS
HPIVARRVVK AHQNGAKIIV CDPRRIEAAR IADQHLQLNN GSNMALVNAF GYVLLEEKLY
NQHYVDRFTE GLDTYREIVK DYAPEAVEHL TGVPAADVRQ AMRTFAAAPS ATIMWGMGVT
QFGQAVDVVR GLAGLALLTG NLGRENVGVG PIRGQNNVQG ACDMGVLPNM FPGYQSVTDP
DVRAKFADAW GISPAVMDEN IGTRITEVPH MALEGKIKAY YIMGEDPLQT EADLSLVRRG
VEALDFLVVQ DIFMTKTAEV ADVLLPATSW GEHGGVFTCA DRGFQRFEKA IEPKGNVKRD
WEIISLIASE MGYPMHYADN QQIWDEMRSL CSLFYGVTYE KMGDMGHIQW PCPTLDHPGT
PYLYQDSHFD TPTGKGKLFA TQWRAPAEVP DEAYPLVLCT VREVGHYSCR SMTGNCAALQ
ALADEPGRVQ MHPQDANRLG IKDRSLVWVS SRRGKVISRA DISERINKGT IYMTYQWWIG
ACNELTQDNL DPISKTPETK YCAAKVDVIE DQRWAEDFAS TSYNDMKARL RAAVAH
//
