ID Q6DD96_MOUSE Unreviewed; 935 AA.
AC Q6DD96;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=Protocadherin gamma subfamily A, 7 {ECO:0000313|EMBL:AAH77712.1, ECO:0000313|Ensembl:ENSMUSP00000141704.2};
GN Name=Pcdhga7 {ECO:0000313|EMBL:AAH77712.1,
GN ECO:0000313|Ensembl:ENSMUSP00000141704.2,
GN ECO:0000313|MGI:MGI:1935219};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH77712.1};
RN [1] {ECO:0000313|EMBL:AAH77712.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH77712.1};
RC TISSUE=Brain {ECO:0000313|EMBL:AAH77712.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000141704.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141704.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000141704.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141704.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BC077712; AAH77712.1; -; mRNA.
DR RefSeq; NP_291068.2; NM_033590.3.
DR STRING; 10090.ENSMUSP00000141704; -.
DR ProteomicsDB; 335124; -.
DR Antibodypedia; 57473; 33 antibodies from 4 providers.
DR DNASU; 93715; -.
DR Ensembl; ENSMUST00000192511.2; ENSMUSP00000141704.2; ENSMUSG00000103472.2.
DR GeneID; 93715; -.
DR KEGG; mmu:93715; -.
DR UCSC; uc008eqt.1; mouse.
DR AGR; MGI:1935219; -.
DR CTD; 56108; -.
DR MGI; MGI:1935219; Pcdhga7.
DR VEuPathDB; HostDB:ENSMUSG00000103472; -.
DR GeneTree; ENSGT00940000164742; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR OMA; LLGTWWE; -.
DR OrthoDB; 5402790at2759; -.
DR BioGRID-ORCS; 93715; 2 hits in 67 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000103472; Expressed in cortical plate and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF56; PROTOCADHERIN GAMMA-A7; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6DD96,
KW ECO:0007829|ProteomicsDB:Q6DD96};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..935
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015098184"
FT TRANSMEM 691..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..135
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 136..244
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 245..349
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 350..454
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 455..564
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 581..685
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 805..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 935 AA; 101559 MW; 6E015096607E9F4E CRC64;
MAPGQRGWGS HYRGFVLLSI LLGMRWEAWA GQILYSVSEE TDKGSFVGNI TKDLGLQPRE
LAERGVRIIT KGKTQLFSLN PRSGSLVTAG RIDREELCAQ SPRCLVSFNI LIEDKMNLYP
IEVEIMDVND NAPRFLTEEI NIKIMENAAP GVRFPLKEAT DSDVGKNSLQ RYQLSPNHHF
SLVVQSGDDG TKYPELVLEK ALDREEEGLH HLVLTAYDGG DPLRSGTASI RVTVVDVNDH
TPVFSLPLYQ ATVPENVPVG TRLLTVNAID LDEGIYGEVT YSFWKITPEL LQIFHLSSLT
GELSTLKGLD YEQSSFYELE VQAQDGAGSL TKAKVLITVL DVNDNAPEVT VTSVSSPVPE
DTPPGTVIAL FYLQDKDSGK NGEVTCSLPE NLPFKLERSI DNYYRLVTAR NLDREKMSVY
NITLKATDGG IPPLSTETRM SIHVSDTNDN PPTFSDSSYS IYVPENNPRG ASIFSVTAQD
PDSDKNAQVT YALAEDTIQG VPVSSYVSIN SDTGILYALG SFDYEQFRDL QLRVTARDSG
DPPLSSNVSL KLFVLDKNDN APEILYPALP TDGSTGVELA PRSAEPGYLV TKVVAVDKDS
GPNAWLSYRL LKASEPGLFS VGLHTGEVRT ARALLDRDAL KQNLVVVVQD HGQPPLSATV
TLTVAVANSI PDVLADLGSI RTPSEPDDSD ITLYLVVAVA TVSCVFLVFV TVLLALRLWR
WHKSHMLQAS SGGGLEDVPA SHFVGLDGVQ AFLQTYSHEV SLTADSRKSH IIFPQPNYVD
TLISQDSCEK SDSLLTSIDF QECKGEAPSS QQAPPNTDWR FSQAQRPGTS GSQNGDETGT
WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
//
