ID Q6DEM2_DANRE Unreviewed; 311 AA.
AC Q6DEM2; A0A8M1N1M4;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 171.
DE RecName: Full=Adapter molecule crk {ECO:0000256|ARBA:ARBA00039213};
GN Name=crk {ECO:0000313|EMBL:AAH77088.1,
GN ECO:0000313|Ensembl:ENSDARP00000072488,
GN ECO:0000313|RefSeq:NP_001003628.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040801-148};
GN Synonyms=fb34h10 {ECO:0000313|RefSeq:NP_001003628.1}, fc05a01
GN {ECO:0000313|RefSeq:NP_001003628.1}, fi19g05
GN {ECO:0000313|RefSeq:NP_001003628.1}, wu:fb34h10
GN {ECO:0000313|RefSeq:NP_001003628.1}, wu:fc05a01
GN {ECO:0000313|RefSeq:NP_001003628.1}, wu:fc54a04
GN {ECO:0000313|RefSeq:NP_001003628.1}, wu:fi19g05
GN {ECO:0000313|RefSeq:NP_001003628.1}, zgc:100936
GN {ECO:0000313|RefSeq:NP_001003628.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH77088.1};
RN [1] {ECO:0000313|EMBL:AAH77088.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAH77088.1};
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH77088.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001003628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003628.1};
RX PubMed=17670792;
RA Moore C.A., Parkin C.A., Bidet Y., Ingham P.W.;
RT "A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor
RT proteins Crk and Crk-like in zebrafish myoblast fusion.";
RL Development 134:3145-3153(2007).
RN [3] {ECO:0000313|RefSeq:NP_001003628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003628.1};
RX PubMed=20047469;
RA Anelli V., Santoriello C., Distel M., Koster R.W., Ciccarelli F.D.,
RA Mione M.;
RT "Global repression of cancer gene expression in a zebrafish model of
RT melanoma is linked to epigenetic regulation.";
RL Zebrafish 6:417-424(2009).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000072488}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000072488};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [5] {ECO:0000313|Ensembl:ENSDARP00000072488, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000072488};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001003628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003628.1};
RX PubMed=27356472;
RA Hu P., Liu M., Liu Y., Wang J., Zhang D., Niu H., Jiang S., Wang J.,
RA Zhang D., Han B., Xu Q., Chen L.;
RT "Transcriptome comparison reveals a genetic network regulating the lower
RT temperature limit in fish.";
RL Sci. Rep. 6:28952-28952(2016).
RN [7] {ECO:0000313|RefSeq:NP_001003628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003628.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|RefSeq:NP_001003628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003628.1};
RX PubMed=29653226;
RA Cao J., Tan X.;
RT "Comparative and evolutionary analysis of the 14-3-3 family genes in eleven
RT fishes.";
RL Gene 662:76-82(2018).
RN [9] {ECO:0000313|Ensembl:ENSDARP00000153352}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000153352};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [10] {ECO:0000313|RefSeq:NP_001003628.1}
RP IDENTIFICATION.
RC STRAIN=Singapore {ECO:0000313|RefSeq:NP_001003628.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the CRK family. {ECO:0000256|ARBA:ARBA00009756}.
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DR EMBL; CR524483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC077088; AAH77088.1; -; mRNA.
DR RefSeq; NP_001003628.1; NM_001003628.2.
DR STRING; 7955.ENSDARP00000072488; -.
DR PaxDb; 7955-ENSDARP00000072488; -.
DR Ensembl; ENSDART00000078024.4; ENSDARP00000072488.3; ENSDARG00000055635.4.
DR Ensembl; ENSDART00000181662.1; ENSDARP00000154923.1; ENSDARG00000115801.1.
DR Ensembl; ENSDART00000188120.1; ENSDARP00000153352.1; ENSDARG00000109497.1.
DR GeneID; 445234; -.
DR KEGG; dre:445234; -.
DR AGR; ZFIN:ZDB-GENE-040801-148; -.
DR CTD; 1398; -.
DR ZFIN; ZDB-GENE-040801-148; crk.
DR eggNOG; KOG4792; Eukaryota.
DR HOGENOM; CLU_060542_0_1_1; -.
DR OMA; QHNPEDD; -.
DR OrthoDB; 2900795at2759; -.
DR TreeFam; TF321436; -.
DR Reactome; R-DRE-170984; ARMS-mediated activation.
DR Reactome; R-DRE-186763; Downstream signal transduction.
DR Reactome; R-DRE-372708; p130Cas linkage to MAPK signaling for integrins.
DR Reactome; R-DRE-4420097; VEGFA-VEGFR2 Pathway.
DR Reactome; R-DRE-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR Reactome; R-DRE-8875555; MET activates RAP1 and RAC1.
DR Reactome; R-DRE-8875656; MET receptor recycling.
DR Reactome; R-DRE-912631; Regulation of signaling by CBL.
DR ChiTaRS; crk; zebrafish.
DR Proteomes; UP000000437; Alternate scaffold 15.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000055635; Expressed in cleaving embryo and 27 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0007520; P:myoblast fusion; IMP:ZFIN.
DR GO; GO:2000145; P:regulation of cell motility; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd09926; SH2_CRK_like; 1.
DR CDD; cd11759; SH3_CRK_C; 1.
DR CDD; cd11758; SH3_CRK_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035458; CRK_SH3_C.
DR InterPro; IPR035457; CRK_SH3_N.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF8; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6DEM2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 13..111
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 133..193
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 242..303
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 193..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 311 AA; 34263 MW; 945885AC0AC03408 CRC64;
MAGNFDSEDR GSWYWGRLSR QEAVSLLQGQ RHGVFLVRDS ITIPGDYVLS VSENSKVSHY
IINSISSNRQ SGPGLAPPRF RIGDQEFDAL PALLEFYKIH YLDTTTLIEP ISKSKHSSFI
SVNAGTGGAP PRLEEEYVRA LFDFPGNDDE DLPFRKGDVL RVLEKPEEQW WNAQNSEGRV
GMIPVPYVEK YRPASPTSGA PGVSVSGSGA HGNSDGHSTQ SPPLLGEPGQ YAQPTSLPNL
QNGPVYARAI QKRVPNAYDK TALALEVGDM VKVTKINVNG QWEGECKGKH GHFPFTHVRL
LDQHNPEDEL S
//
