ID Q6DF25_XENTR Unreviewed; 928 AA.
AC Q6DF25; F6QNJ3; F6YK73;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE SubName: Full=Zinc fingers and homeoboxes 3 {ECO:0000313|EMBL:AAH76918.1};
DE SubName: Full=Zinc fingers and homeoboxes protein 3 {ECO:0000313|RefSeq:NP_001006839.1};
GN Name=zhx3 {ECO:0000313|EMBL:AAH76918.1,
GN ECO:0000313|RefSeq:NP_001006839.1,
GN ECO:0000313|Xenbase:XB-GENE-853511};
GN Synonyms=tix1 {ECO:0000313|RefSeq:NP_001006839.1};
GN ORFNames=TEgg069p20.1-001 {ECO:0000313|EMBL:CAJ82286.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH76918.1};
RN [1] {ECO:0000313|RefSeq:NP_001006839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH76918.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH76918.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAJ82286.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001006839.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR EMBL; BC076918; AAH76918.1; -; mRNA.
DR EMBL; CR942443; CAJ82286.1; -; mRNA.
DR RefSeq; NP_001006839.1; NM_001006838.1.
DR STRING; 8364.ENSXETP00000042820; -.
DR PaxDb; 8364-ENSXETP00000042167; -.
DR DNASU; 448584; -.
DR GeneID; 448584; -.
DR KEGG; xtr:448584; -.
DR AGR; Xenbase:XB-GENE-853511; -.
DR CTD; 23051; -.
DR Xenbase; XB-GENE-853511; zhx3.
DR eggNOG; ENOG502RC6G; Eukaryota.
DR HOGENOM; CLU_009147_1_0_1; -.
DR OMA; YYVTHKM; -.
DR OrthoDB; 5350395at2759; -.
DR TreeFam; TF333363; -.
DR Proteomes; UP000008143; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF6; ZINC FINGERS AND HOMEOBOXES PROTEIN 3; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR Pfam; PF11569; Homez; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 5.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 315..358
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 487..547
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 609..657
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 740..800
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 317..359
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 489..548
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 611..658
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 742..801
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 104262 MW; 7E8C12568EDB9F4D CRC64;
MASKRKSTTP CMIPLKTLAP DRGTDISEEC KEKSAKQEDQ EILQALDLSE SSNVVQSNGH
ENVDGDKYFC KYCNFGSHDT KPFIEHMLSK HTGFKEDPSY VCIACSFLVK DYKELEAHNA
ESHLESNLTW SVAKHESYTI VEQSLTDHNT DSIMAQHLPE QGVDEFSEIS ITKTPIMKIR
KNKPETKKII AMKDSNHLSE EVEKKPHLLS SNGLLPGNKV INKVVGSSPV VNGSIIGTVP
LLQTGVTQLL SIDPSQSVMQ PKLPTLISPV LTKPYVAPKS HHITQPPTAK NLPKVMIPLS
SIPTYNVSMD SNCFLKNSFN KFPYPTKAEL CYLTVVTKYP EEQIKIWFTA QRLKQGISWT
PEEIEDSRKK MFNTIIQSIP QPMPQPTITV LNAPLVTNTN HVQPLIQASL PGHIVNQPQG
ASGLLVTQPI IPNGIQAAST AVSLSMTNIP SHQATTQTMS SSPAIRVVGS TRPVTPTSPT
MLSQSLYDST SNRSKKSRQQ LTALKNSFYR SQFPSHGEVA RLTKITGLNT RDVRKWFSDK
RYHWRNKATN AIDSSSSMLD TSADITYSML KEHDLALQTH ASASSHTTRR HSWNPTPDFT
PKYKERAPEQ VRALEKSFFQ SSFPTVEEVN RLRSETKMTR REIDSWFAEK RKRVAEENKK
AKIGDQDFDE IEDSADELII SENIGSPPAE SIVHIPSERK VNPIKINLKD LRVTESNDCA
EMSSENDNSM SFDVESAAVP SPKIRHIKKT PQQREILKHM FIQTQWPTND EYDHIIEQTG
LSRTDVVRWF GDCRYSFKNG QLRWYDRYKR GMAQLKPVSC QPLLDYYSQH HLVYDCDLDG
LCEQTGLTAE EVKSWFAHKM EEEARAVSEA GGEGLHSDIG DKAVAQMETY DGVSEMSENS
ESWEPAAPEP HTAAVQLEQQ SSTEQQST
//
