ID Q6DFM4_XENTR Unreviewed; 248 AA.
AC Q6DFM4; F7C654;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Tropomyosin 1 {ECO:0000313|EMBL:AAH76711.1, ECO:0000313|Ensembl:ENSXETP00000003279};
DE SubName: Full=Tropomyosin alpha-1 chain {ECO:0000313|RefSeq:NP_001005028.1};
GN Name=tpm1 {ECO:0000313|EMBL:AAH76711.1,
GN ECO:0000313|Ensembl:ENSXETP00000003279,
GN ECO:0000313|RefSeq:NP_001005028.1,
GN ECO:0000313|Xenbase:XB-GENE-485946};
GN Synonyms=alpha-tm {ECO:0000313|RefSeq:NP_001005028.1}, CH1
GN {ECO:0000313|RefSeq:NP_001005028.1}, htm-alpha
GN {ECO:0000313|RefSeq:NP_001005028.1}, tm3
GN {ECO:0000313|RefSeq:NP_001005028.1}, tmsa
GN {ECO:0000313|RefSeq:NP_001005028.1}, tpm1-alpha
GN {ECO:0000313|RefSeq:NP_001005028.1}, tpm1-kappa
GN {ECO:0000313|RefSeq:NP_001005028.1}, tpm3
GN {ECO:0000313|RefSeq:NP_001005028.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH76711.1};
RN [1] {ECO:0000313|RefSeq:NP_001005028.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH76711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH76711.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000003279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000003279};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000003279}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001005028.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the tropomyosin family.
CC {ECO:0000256|ARBA:ARBA00009036, ECO:0000256|RuleBase:RU004515}.
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DR EMBL; BC076711; AAH76711.1; -; mRNA.
DR RefSeq; NP_001005028.1; NM_001005028.1.
DR DNASU; 448541; -.
DR Ensembl; ENSXETT00000003279; ENSXETP00000003279; ENSXETG00000009718.
DR GeneID; 448541; -.
DR KEGG; xtr:448541; -.
DR AGR; Xenbase:XB-GENE-485946; -.
DR CTD; 7168; -.
DR Xenbase; XB-GENE-485946; tpm1.
DR HOGENOM; CLU_055027_3_0_1; -.
DR OrthoDB; 5398117at2759; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000009718; Expressed in heart and 26 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.370; -; 1.
DR InterPro; IPR000533; Tropomyosin.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR19269; TROPOMYOSIN; 1.
DR PANTHER; PTHR19269:SF79; TROPOMYOSIN BETA CHAIN; 1.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 2: Evidence at transcript level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT REGION 18..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 248 AA; 29016 MW; 6E26FACC2340F598 CRC64;
MAGITSLEAV KRKIKCLQDQ ADAAEERAEK LQRERDMERK QREAAEGDVA SLNRRIQLVE
EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRALK DEEKMELQEI QLKEAKHIAE
EADRKYEEVA RKLVIIEGDL ERAEERAELS ESRYRQLDDQ LRIMDQTLKT LMAAEEKYSQ
KEDKYEEEIK VLTDKLKEAE TRAEFAERTV AKLEKTIDDL EEKVTHAKEE NLNMHQMLDQ
TLLELNNM
//
