ID WDR83_DANRE Reviewed; 315 AA.
AC Q6DH44;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=WD repeat domain-containing protein 83;
DE AltName: Full=Mitogen-activated protein kinase organizer 1;
DE Short=MAPK organizer 1;
GN Name=wdr83; Synonyms=morg1; ORFNames=zgc:92654;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Molecular scaffold protein for various multimeric protein
CC complexes. Acts as a module in the assembly of a multicomponent
CC scaffold for the ERK pathway, linking ERK responses to specific
CC agonists. Also involved in response to hypoxia by acting as a negative
CC regulator of HIF1A/HIF-1-alpha (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat MORG1 family. {ECO:0000305}.
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DR EMBL; BC076138; AAH76138.1; -; mRNA.
DR RefSeq; NP_001002429.1; NM_001002429.1.
DR AlphaFoldDB; Q6DH44; -.
DR SMR; Q6DH44; -.
DR STRING; 7955.ENSDARP00000060977; -.
DR PaxDb; 7955-ENSDARP00000060977; -.
DR GeneID; 436702; -.
DR KEGG; dre:436702; -.
DR AGR; ZFIN:ZDB-GENE-040718-126; -.
DR CTD; 84292; -.
DR ZFIN; ZDB-GENE-040718-126; wdr83.
DR eggNOG; KOG0316; Eukaryota.
DR InParanoid; Q6DH44; -.
DR OrthoDB; 24036at2759; -.
DR PhylomeDB; Q6DH44; -.
DR Reactome; R-DRE-5674135; MAP2K and MAPK activation.
DR PRO; PR:Q6DH44; -.
DR Proteomes; UP000000437; Alternate scaffold 22.
DR Proteomes; UP000000437; Chromosome 22.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22842:SF3; WD REPEAT DOMAIN-CONTAINING PROTEIN 83; 1.
DR PANTHER; PTHR22842; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..315
FT /note="WD repeat domain-containing protein 83"
FT /id="PRO_0000235266"
FT REPEAT 23..62
FT /note="WD 1"
FT REPEAT 65..104
FT /note="WD 2"
FT REPEAT 107..146
FT /note="WD 3"
FT REPEAT 151..188
FT /note="WD 4"
FT REPEAT 189..228
FT /note="WD 5"
FT REPEAT 233..272
FT /note="WD 6"
FT REPEAT 275..313
FT /note="WD 7"
SQ SEQUENCE 315 AA; 34795 MW; 1578D04EFF728921 CRC64;
MAFPQPRPQA PQLPQHLWRT VDCQQGAVRA VRFNADGNYL LTCGSDKSLK LWSVSRGTLL
KTYSGHGYEV LDADGSYDNS QLCSCSSDKT VILWDVASGQ VTRKLRGHAG KVNCVQFNEE
ATVMLSGSID GTVRCWDTRS RRMEPIQILD ESQDGISSLK VSEHELLTGS VDGRVRRYDL
RMGQLQVDYI GSPITCVCFS RDGQCTLSSS LDSTVRLLDK STGEMLGEYS GHVNKGYKLD
CCLTDKDTHV LSCSEDGHVY YWDLVEGSLT LKLPVGKAVV QSLSFHPTEP RLLTSMEGRV
QVWGAEPEDA AENES
//
