ID Q6DHN2_DANRE Unreviewed; 404 AA.
AC Q6DHN2; A0A8M1N0S1; F1R6H7;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=Death effector domain-containing {ECO:0000313|Ensembl:ENSDARP00000042866, ECO:0000313|RefSeq:NP_001002639.1};
DE SubName: Full=Death effector domain-containing protein isoform X1 {ECO:0000313|RefSeq:XP_005166883.1};
DE SubName: Full=Zgc:92202 {ECO:0000313|EMBL:AAH75935.1};
GN Name=dedd {ECO:0000313|Ensembl:ENSDARP00000042866,
GN ECO:0000313|RefSeq:NP_001002639.1, ECO:0000313|RefSeq:XP_005166883.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040718-386};
GN Synonyms=fk97g03 {ECO:0000313|RefSeq:NP_001002639.1}, wu:fk97g03
GN {ECO:0000313|RefSeq:NP_001002639.1,
GN ECO:0000313|RefSeq:XP_005166883.1};
GN ORFNames=zgc:92202 {ECO:0000313|EMBL:AAH75935.1,
GN ECO:0000313|RefSeq:NP_001002639.1, ECO:0000313|RefSeq:XP_005166883.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH75935.1};
RN [1] {ECO:0000313|EMBL:AAH75935.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH75935.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000107603}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107603};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000042866}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000042866};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000042866, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000042866};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001002639.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001002639.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_001002639.1, ECO:0000313|RefSeq:XP_005166883.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005166883.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; BX248385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC075935; AAH75935.1; -; mRNA.
DR RefSeq; NP_001002639.1; NM_001002639.1.
DR RefSeq; XP_005166883.1; XM_005166826.4.
DR STRING; 7955.ENSDARP00000042866; -.
DR PaxDb; 7955-ENSDARP00000042866; -.
DR Ensembl; ENSDART00000042867.6; ENSDARP00000042866.5; ENSDARG00000029783.7.
DR Ensembl; ENSDART00000124849.3; ENSDARP00000107603.2; ENSDARG00000029783.7.
DR GeneID; 436912; -.
DR KEGG; dre:436912; -.
DR AGR; ZFIN:ZDB-GENE-040718-386; -.
DR CTD; 9191; -.
DR ZFIN; ZDB-GENE-040718-386; dedd.
DR eggNOG; ENOG502QRWB; Eukaryota.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_053869_0_0_1; -.
DR OMA; QAWPEEE; -.
DR OrthoDB; 3058503at2759; -.
DR TreeFam; TF315472; -.
DR TreeFam; TF331807; -.
DR Proteomes; UP000000437; Chromosome 8.
DR Bgee; ENSDARG00000029783; Expressed in testis and 28 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08790; DED_DEDD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR038856; DEDD/DEDD2.
DR InterPro; IPR049341; TRADD-like_N.
DR PANTHER; PTHR15205; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15205:SF2; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 1.
DR Pfam; PF20694; TRADD-like_N; 1.
DR SMART; SM00031; DED; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50168; DED; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 104..182
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 44888 MW; 3C949D8B3B07B81A CRC64;
MTSQQHGNAN PALLSPQNSS SSQGRQHISR SPIDSYSRSG LSSPRRGWVA ASSSGTTHGN
SLALSLSRLA PASSSNSSST RRPASGRVEP WPEEAVDDAY GLYSLHRMFD IVGAQLTHRD
VRVLSFLFVD VIDEYERGGI RSGRDFLLAL ERQGRCDETN FRHVLQLLRI ITRHDLLPYV
TLRKRQTVCP DPVDKYLEET SVRYVSPRGT ADAQQGTPHR RTGPQPLICC PPSGPQVCPP
RAKPAPPPPS RKRKRSHTTA DCREKQTCDI RLRVRAEYCQ HESALQGNVF SNKQEALERQ
FERFNQANTI LKSRDLGSII CDIKFSELTY LDAFWRDYIN GSLLEALKGV FITDSLKQAV
GHEAIKLLVN VDEEDYQAGR RKLLRNLVAG GAGAGTGSRE SPLS
//
