Database: UniProt
Entry: Q6DJ00
LinkDB: Q6DJ00
Original site: Q6DJ00 
ID   OSTCN_XENTR             Reviewed;         101 AA.
AC   Q6DJ00;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   RecName: Full=Osteocalcin;
DE   AltName: Full=Bone Gla protein;
DE            Short=BGP;
DE   AltName: Full=Gamma-carboxyglutamic acid-containing protein;
DE   Flags: Precursor;
GN   Name=bglap;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds strongly to apatite and calcium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Gamma-carboxyglutamate residues are formed by vitamin K
CC       dependent carboxylation. These residues are essential for the
CC       binding of calcium. {ECO:0000255|PROSITE-ProRule:PRU00463}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
DR   EMBL; BC075385; AAH75385.1; -; mRNA.
DR   RefSeq; NP_001006689.1; NM_001006688.1.
DR   SMR; Q6DJ00; -.
DR   STRING; 8364.ENSXETP00000005554; -.
DR   PRIDE; Q6DJ00; -.
DR   GeneID; 448310; -.
DR   KEGG; xtr:448310; -.
DR   CTD; 632; -.
DR   Xenbase; XB-GENE-1018467; bglap.
DR   InParanoid; Q6DJ00; -.
DR   KO; K22609; -.
DR   OrthoDB; 1520921at2759; -.
DR   Reactome; R-XTR-159740; Gamma-carboxylation of protein precursors.
DR   Reactome; R-XTR-159763; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
DR   Reactome; R-XTR-159782; Removal of aminoterminal propeptides from gamma-carboxylated proteins.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0046848; F:hydroxyapatite binding; IBA:GO_Central.
DR   GO; GO:0008147; F:structural constituent of bone; IBA:GO_Central.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   GO; GO:0060348; P:bone development; IBA:GO_Central.
DR   GO; GO:0001503; P:ossification; IBA:GO_Central.
DR   GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   GO; GO:1900076; P:regulation of cellular response to insulin stimulus; IEA:InterPro.
DR   GO; GO:0032571; P:response to vitamin K; IEA:InterPro.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR039176; Osteocalcin.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   PANTHER; PTHR14235; PTHR14235; 1.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   3: Inferred from homology;
KW   Biomineralization; Calcium; Cleavage on pair of basic residues;
KW   Complete proteome; Disulfide bond; Gamma-carboxyglutamic acid;
KW   Metal-binding; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   PROPEP       19     52       {ECO:0000250}.
FT                                /FTId=PRO_0000011102.
FT   CHAIN        53    101       Osteocalcin.
FT                                /FTId=PRO_0000011103.
FT   DOMAIN       53     99       Gla. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   METAL        69     69       Calcium 3. {ECO:0000250}.
FT   METAL        73     73       Calcium 2. {ECO:0000250}.
FT   METAL        76     76       Calcium 1. {ECO:0000250}.
FT   METAL        76     76       Calcium 2. {ECO:0000250}.
FT   METAL        82     82       Calcium 1. {ECO:0000250}.
FT   MOD_RES      69     69       4-carboxyglutamate. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   MOD_RES      73     73       4-carboxyglutamate. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   MOD_RES      76     76       4-carboxyglutamate. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   DISULFID     75     81       {ECO:0000255|PROSITE-ProRule:PRU00463}.
SQ   SEQUENCE   101 AA;  11160 MW;  8BD1C845E0CBD02C CRC64;
DBGET integrated database retrieval system