ID Q6DKC3_XENLA Unreviewed; 383 AA.
AC Q6DKC3;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=ethanolamine-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00024221};
DE EC=2.7.7.14 {ECO:0000256|ARBA:ARBA00024221};
DE AltName: Full=CTP:phosphoethanolamine cytidylyltransferase {ECO:0000256|ARBA:ARBA00031473};
GN Name=pcyt2.L {ECO:0000313|RefSeq:NP_001086220.1,
GN ECO:0000313|Xenbase:XB-GENE-978341};
GN Synonyms=MGC84177 {ECO:0000313|EMBL:AAH74341.1}, pcyt2
GN {ECO:0000313|RefSeq:NP_001086220.1,
GN ECO:0000313|Xenbase:XB-GENE-978341};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH74341.1};
RN [1] {ECO:0000313|RefSeq:NP_001086220.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH74341.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAH74341.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001086220.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC {ECO:0000256|ARBA:ARBA00024191}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; BC074341; AAH74341.1; -; mRNA.
DR RefSeq; NP_001086220.1; NM_001092751.1.
DR STRING; 8355.Q6DKC3; -.
DR PaxDb; 8355-Q6DKC3; -.
DR DNASU; 444649; -.
DR GeneID; 444649; -.
DR KEGG; xla:444649; -.
DR AGR; Xenbase:XB-GENE-978341; -.
DR CTD; 444649; -.
DR Xenbase; XB-GENE-978341; pcyt2.L.
DR OMA; CGVHNDE; -.
DR OrthoDB; 5474784at2759; -.
DR UniPathway; UPA00558; UER00742.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 444649; Expressed in intestine and 19 other cell types or tissues.
DR GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02174; CCT; 1.
DR CDD; cd02173; ECT; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR044608; Ect1/PCYT2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 2.
DR PANTHER; PTHR45780; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR45780:SF2; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 2: Evidence at transcript level;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|RefSeq:NP_001086220.1};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..147
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 214..305
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 383 AA; 43870 MW; 19E81EC4FF688B37 CRC64;
MMRNGYPEQA LDKESVRRPV RVWCDGCYDM VHYGHSNQLR QARAMGDYLI VGVHTDEEIS
QHKGPPVFTQ DERYKMVKAI KWVDEIVPGA PYVTTLETLD KYNCDFCVHG NDITLTVDGK
DTYEEVKNAG RYRECQRTQG VSTTDLVGRM LLMTKAHHSM EVTLDYQKHQ NNLSKDARGH
SPWTGVSQFL QTSQKIMQFA SGKEPSPEDT IIYVAGAFDL FHIGHIDFLE KVYSLVEKPY
VIVGLHFDQE VNHYKRKNYP IMNIHERTLS VLACRYVAEV VIGAPYSVSA DLLDHFKVDI
VCHGKTDVLP DRDGSDPYAE PKQRGIFRAV DSGNSLTTDD IVQRIIKNRL EYEARNQKKE
AKELAVFEAQ QRREHIINGQ ESK
//
