ID Q6E5T5_TAKRU Unreviewed; 211 AA.
AC Q6E5T5;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
GN Name=cldn1 {ECO:0000313|EMBL:AAT64078.1};
GN Synonyms=LOC101065380 {ECO:0000313|Ensembl:ENSTRUP00000003701.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAT64078.1};
RN [1] {ECO:0000313|EMBL:AAT64078.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15197168; DOI=10.1101/gr.2400004;
RA Loh Y.H., Christoffels A., Brenner S., Hunziker W., Venkatesh B.;
RT "Extensive expansion of the claudin gene family in the teleost fish, Fugu
RT rubripes.";
RL Genome Res. 14:1248-1257(2004).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000003701.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000003701.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000256|RuleBase:RU060637}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|RuleBase:RU060637}. Cell membrane
CC {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU060637}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295, ECO:0000256|RuleBase:RU060637}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU060637}.
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DR EMBL; AY554352; AAT64078.1; -; Genomic_DNA.
DR RefSeq; XP_003975798.1; XM_003975749.2.
DR STRING; 31033.ENSTRUP00000003701; -.
DR Ensembl; ENSTRUT00000003721.3; ENSTRUP00000003701.1; ENSTRUG00000001602.3.
DR GeneID; 101065380; -.
DR KEGG; tru:101065380; -.
DR CTD; 9076; -.
DR eggNOG; ENOG502R7HF; Eukaryota.
DR GeneTree; ENSGT00940000155387; -.
DR HOGENOM; CLU_076370_2_3_1; -.
DR OMA; RCTTCMA; -.
DR OrthoDB; 4040914at2759; -.
DR TreeFam; TF331936; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF92; CLAUDIN-1; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PRINTS; PR01385; CLAUDIN14.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW ECO:0000256|RuleBase:RU060637};
KW Cell membrane {ECO:0000256|RuleBase:RU060637};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU060637};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427,
KW ECO:0000256|RuleBase:RU060637};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU060637};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU060637}.
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT TRANSMEM 118..141
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT TRANSMEM 161..184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT REGION 188..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 22630 MW; 5324ED5B19CD3399 CRC64;
MANAGIQLLG FILAFLGLIG TIASTIMVEW KASSYAGDNI ITAQAMYEGL WKSCVSQSTG
QIQCKVYDSL LQLPGIVQGT RGLMLASVLL SVICLLVEMV GMRCTTFMAE EPEQKDKVAL
AGGVIFIIAG LLALVGTSWY GHRIAREFYD PFTPTNSRYE FGSALYVGWG AACLTLIGGG
FLCCSCPKKG SQKSPRYPPT RSSGPQGKDY V
//