ID UVRC_MESFL Reviewed; 588 AA.
AC Q6F216;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Mfl101;
OS Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
OS (Acholeplasma florum).
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales;
OC Entomoplasmataceae; Mesoplasma.
OX NCBI_TaxID=265311;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1;
RA Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
RA Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; AE017263; AAT75457.1; -; Genomic_DNA.
DR RefSeq; WP_011182998.1; NC_006055.1.
DR RefSeq; YP_053341.1; NC_006055.1.
DR AlphaFoldDB; Q6F216; -.
DR SMR; Q6F216; -.
DR STRING; 265311.Mfl101; -.
DR PaxDb; 265311-Mfl101; -.
DR EnsemblBacteria; AAT75457; AAT75457; Mfl101.
DR GeneID; 2897800; -.
DR KEGG; mfl:Mfl101; -.
DR PATRIC; fig|265311.5.peg.102; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_14; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000006647; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..588
FT /note="UvrABC system protein C"
FT /id="PRO_0000227444"
FT DOMAIN 12..89
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 194..229
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 588 AA; 68928 MW; 818F062896B35FFA CRC64;
MELKNKVSNL PSKPGCYLYL NKDKHVIYVG KAKNLKKRVS SYFDRAQNLK TTRLVREIAD
LEYFVVSNEK ESLLLEENLI KKYRPKYNVL LNDDKAYPYI IITNEKDPTY KYVRKLDKKA
FRSFGPLPIG SNARETLITL QRLFPLRRCK GNLGKPCLHY FIGQCSGACF KEVNKEYYQE
QIKRVDNFFK GNINEVKTLL TNQMHKAAEN LQFEEAQRIK EQIISLDFTT TKQNVEFKSQ
TDVDVISYFI EDEKIAIVTL FYRSGKLLFK DEHIQLYFEQ DITDLIDSFM SQIYDKNILP
DKIIVDNEVE LFDLNEKYKS ISTHPIKEDE KIIYKLATEN AQEAIRKSKI STTINIGNEN
ELLLELQEKA NLQKEPYRLE MFDISNIGNE FIVGSCVVYI NGKPARNEFR KYNIESKFTS
DYDRLKEMLY RRFQKALIEK RMLPDLIIMD GGIIQIHAAK EIINALGLSE IQVIGLVKDE
HHNTSFLIDT NEEQVIIKDK PKLFNWLSSI QVRVDEYAKS GFRKKQNNSF LKSDLEQIEG
LGKKRIQDLF KKFNTINEIE SADQEELFKI LKNKKALDNL NIYLKNRK
//
