ID Q6F6A1_ORYLA Unreviewed; 336 AA.
AC Q6F6A1; H2N2S1;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Cathepsin L {ECO:0000313|EMBL:BAD27581.1, ECO:0000313|Ensembl:ENSORLP00000025760.2};
GN Name=ctsL {ECO:0000313|EMBL:BAD27581.1};
GN Synonyms=ctsla {ECO:0000313|Ensembl:ENSORLP00000025760.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:BAD27581.1};
RN [1] {ECO:0000313|EMBL:BAD27581.1}
RP NUCLEOTIDE SEQUENCE.
RA Ogiwara K., Takahashi T.;
RT "Cloning of cathepsin L in the medaka fish Oryzias latipes.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025760.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025760.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [3] {ECO:0000313|Ensembl:ENSORLP00000025760.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025760.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB099890; BAD27581.1; -; mRNA.
DR RefSeq; NP_001098156.1; NM_001104686.1.
DR STRING; 8090.ENSORLP00000025760; -.
DR MEROPS; C01.032; -.
DR Ensembl; ENSORLT00000025761.2; ENSORLP00000025760.2; ENSORLG00000020801.2.
DR GeneID; 100049246; -.
DR KEGG; ola:100049246; -.
DR CTD; 321453; -.
DR eggNOG; KOG1543; Eukaryota.
DR GeneTree; ENSGT00940000153321; -.
DR HOGENOM; CLU_012184_1_2_1; -.
DR OrthoDB; 5472948at2759; -.
DR TreeFam; TF313739; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000020801; Expressed in mesonephros and 15 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..336
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041118818"
FT DOMAIN 28..87
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 115..335
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 336 AA; 38160 MW; 80F8587ACE822C95 CRC64;
MLPLALLAVC ACAALSAPTL DPQLDQHWQL WKGWHSKNYH EKEEGWRRLV WEKNLRKIEL
HNLEHSMGKH SYRLGMNHFG DMTHEEFRQI MNGYKRREQR KYSGSLFMEP NFLEAPRAVD
WRDKGYVTPV KDQGQCGSCW AFSTTGALEG QQFRKTGKLV SLSEQNLVDC SRPEGNEGCN
GGLMDQAFQY VKDNQGLDSE DFYPYKGTDD QPCQYNAQYS AVNDTGFVDI PSGKERALMK
AVASVGPVSV AIDAGHESFQ FYQSGIYFEK ECSSDELDHG VLVVGYGFEG EDVDGKKYWI
VKNSWSEKWG DKGFIYMAKD RHNHCGIATA ASYPLV
//
