ID MUTS_ACIAD Reviewed; 881 AA.
AC Q6FC54;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ACIAD1500;
OS Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=62977;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33305 / BD413 / ADP1;
RX PubMed=15514110; DOI=10.1093/nar/gkh910;
RA Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT a versatile and naturally transformation competent bacterium.";
RL Nucleic Acids Res. 32:5766-5779(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CR543861; CAG68357.1; -; Genomic_DNA.
DR RefSeq; WP_004925309.1; NC_005966.1.
DR AlphaFoldDB; Q6FC54; -.
DR SMR; Q6FC54; -.
DR STRING; 202950.GCA_001485005_02067; -.
DR GeneID; 45233906; -.
DR KEGG; aci:ACIAD1500; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OrthoDB; 9802448at2; -.
DR BioCyc; ASP62977:ACIAD_RS06920-MONOMER; -.
DR Proteomes; UP000000430; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..881
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224343"
FT BINDING 632..639
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 881 AA; 98577 MW; 40CDADEA4E5A3F90 CRC64;
MNSTETMADL SSYTPMMQQY FKVKLEHQHA LLFYRMGDFY ELFFDDARKA AKLLGITLTH
RGKANGEPIP MAGVPYHAAE GYLARLVRAG QTVAICEQVG EGENAGSRCK APMERKVVRI
ITPGTITDDA LLGSYQSSNL VALCIQQNKI GIALLDLSAS IFKVQQHEFK TEQLYIELAR
LMPSEIVVDE DLVDQNILEQ IKKQIECSIT KRPNVDFNLN NAQKTLCDQF GVTTLSGFGI
DHLPLAKAAA AALIHYAKET QKTALPHIRS IQLEQSTDFI ALDPITRRNL EIIDPLFEHG
TSLFNLINDC QTAMGGRLLS RILMQPIRDT AILDARLDAT EQLLIGYHES PVRLVLKEIG
DIERVLSRVA LGTARPRDLV QLRQACAQIP FLRHALLPAI QTKSSKLLNE LDHELGDFKD
LHQLLLSAIV ENPPVLLRDG NVIAEGYDAE LDELRKIRDH AGQFLVDLEI KERESSGIPT
LKIGYNRVSG YYIELTRAQA EQAPAYYIRR QTLKNAERYI TPELKSFEDK VLSSESRALA
REKLLFESLL ETLKKNIANL QMMSSAIAQI DVLANFAHQA RLQNWNRPDF SPEIGIKIHD
GRHPVVEALS KTPYTPNDTF LDSQHRMAII TGPNMGGKST FMRQTALISL LAYCGSYVPA
KSAKLGPIDR IFTRIGSADD LSTGKSTFMV EMTETSQILH HATHQSLVLM DEVGRGTSTY
DGLSLAWACV LDLTKRIKCL CLFATHYFEL TELGSESAID NYHVTAKEMN GNLILLHKVQ
HGPASQSHGL QVAKLAGIPA SVIKEAQKRL KILEKQQQQY FQTAVQNDLF AIPELPQIDE
TKIEIKKTSP VLDHLKQLDV DSLTPRQALE ALYQLKDQLE H
//
