ID Q6FJP6_CANGA Unreviewed; 298 AA.
AC Q6FJP6;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Candida glabrata strain CBS138 chromosome M complete sequence {ECO:0000313|EMBL:CAG62524.1};
GN Name=SPE4 {ECO:0000313|CGD:CAL0136643};
GN OrderedLocusNames=CAGL0M04609g {ECO:0000313|CGD:CAL0136643,
GN ECO:0000313|EMBL:CAG62524.1};
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593 {ECO:0000313|EMBL:CAG62524.1, ECO:0000313|Proteomes:UP000002428};
RN [1] {ECO:0000313|EMBL:CAG62524.1, ECO:0000313|Proteomes:UP000002428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC {ECO:0000313|Proteomes:UP000002428};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867, ECO:0000256|RuleBase:RU003836}.
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DR EMBL; CR380959; CAG62524.1; -; Genomic_DNA.
DR RefSeq; XP_449548.1; XM_449548.1.
DR AlphaFoldDB; Q6FJP6; -.
DR STRING; 284593.Q6FJP6; -.
DR EnsemblFungi; CAGL0M04609g-T; CAGL0M04609g-T-p1; CAGL0M04609g.
DR GeneID; 2891557; -.
DR KEGG; cgr:CAGL0M04609g; -.
DR CGD; CAL0136643; SPE4.
DR VEuPathDB; FungiDB:CAGL0M04609g; -.
DR eggNOG; KOG1562; Eukaryota.
DR HOGENOM; CLU_048199_1_0_1; -.
DR InParanoid; Q6FJP6; -.
DR OMA; HIYNEMI; -.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0016768; F:spermine synthase activity; IEA:EnsemblFungi.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006597; P:spermine biosynthetic process; IEA:EnsemblFungi.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.30.140.10; Spermidine synthase, tetramerisation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR030373; PABS_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR030668; Spermi_synthase_euk.
DR InterPro; IPR035246; Spermidine_synt_N.
DR InterPro; IPR037163; Spermidine_synt_N_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR NCBIfam; TIGR00417; speE; 1.
DR PANTHER; PTHR11558:SF11; SPERMIDINE SYNTHASE; 1.
DR PANTHER; PTHR11558; SPERMIDINE/SPERMINE SYNTHASE; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR PIRSF; PIRSF000502; Spermidine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01330; PABS_1; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 9..251
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 170
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 298 AA; 33700 MW; FD4D2D9A53869418 CRC64;
MAEQKYIKDG WFYEMSDEHF PGQALALKVK QVLYQSKSEF QDILVFESTN HGVCLVLDGI
IQCSERDEFA YQEMIAHIPL YCHANPKKVL VIGGGDGGVV REVVKHDKVE SVTMVEIDKT
VIELAKKYLP GMSCAMDHPK LKLNLCDGFK FLKEASMLSN DDKYDVIITD SSDPDGPAEA
FFQKEYFELL QNALKPDGIV IAQASENVWL DINYLASLRK TANEVFTNTM ISYTTVPTYT
SGQLGLIVCT NSNDYDLTTP QRQPSVSEQN QLRYYNSQIH SASFVLPNWA DMLIYDKK
//
