ID Q6FMY0_CANGA Unreviewed; 647 AA.
AC Q6FMY0;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN OrderedLocusNames=CAGL0K04345g {ECO:0000313|CGD:CAL0134761,
GN ECO:0000313|EMBL:CAG61375.1};
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593 {ECO:0000313|EMBL:CAG61375.1, ECO:0000313|Proteomes:UP000002428};
RN [1] {ECO:0000313|EMBL:CAG61375.1, ECO:0000313|Proteomes:UP000002428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC {ECO:0000313|Proteomes:UP000002428};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR EMBL; CR380957; CAG61375.1; -; Genomic_DNA.
DR RefSeq; XP_448414.1; XM_448414.1.
DR AlphaFoldDB; Q6FMY0; -.
DR STRING; 284593.Q6FMY0; -.
DR EnsemblFungi; CAGL0K04345g-T; CAGL0K04345g-T-p1; CAGL0K04345g.
DR GeneID; 2889993; -.
DR KEGG; cgr:CAGL0K04345g; -.
DR CGD; CAL0134761; CAGL0K04345g.
DR VEuPathDB; FungiDB:CAGL0K04345g; -.
DR eggNOG; KOG2315; Eukaryota.
DR HOGENOM; CLU_013809_0_1_1; -.
DR InParanoid; Q6FMY0; -.
DR OMA; WNPNSKE; -.
DR Proteomes; UP000002428; Chromosome K.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:EnsemblFungi.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 229..428
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 479..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 71776 MW; 9517F393717C9F69 CRC64;
MSSQFFLKTS KDIELFQGYP DFTQSNSAAN AKDDQVISSV LSPCGRFFAI STKGNVKVFS
GELLEVELLN LTINDVYEIQ FSPSGNYMST WERPSAKDAE HKNVKVWYLN KVFTEGEEQE
PVFQYQHKPQ NGWFMQFSKL DDYALKMFKN EIRIVKINDA NKTNFHFDQP FATLSKTQEN
DSQPFSTYQV SPADFPTICT FTPEKGGKPA QLSIWSITEG KITKKIASKT FFKADSCQLQ
WNPQGNAVLC VATTDFDSTN KSYYGENTLY LLSFQGVNGA VGNNSVRVSL AKGPVHDISW
SPTSRQFGVI SGYMPATIQF FDLRGNVVHS LEKQPKNTIL FSPSGRYILI AGFGNLQGSV
QILDRHDKFK SLTVFNAANT SVCKWSPGGE FIMTATTSPR LRVDNCIKIW HVSGTLVFAK
EFEELLKVDW RNTCKYKTLK DHPHVIKDWT PLNNTDAASL DPQIASPKKD LAIHESAKEY
EAKHPKRDAK TGNGSTQSKS ASTGGAYKPP HARRAAAVAN NRSVPGASPK VQRAIPGLIP
GLPVNEGSAA ANKNRKRRAN KKANSGTGEG AEKAESPAAP SITSTEPAKE ASPEEKKIRS
LLKKLRAIEM LKEKQAAGEK LQDLQVKKIE TEGKFREELA ALGWKEE
//
