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Database: UniProt
Entry: Q6FPT7
LinkDB: Q6FPT7
Original site: Q6FPT7 
ID   DBP4_CANGA              Reviewed;         765 AA.
AC   Q6FPT7;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   16-OCT-2019, entry version 106.
DE   RecName: Full=ATP-dependent RNA helicase DBP4;
DE            EC=3.6.4.13;
GN   Name=DBP4; OrderedLocusNames=CAGL0J01045g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-dependent RNA helicase required for ribosome
CC       biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal
CC       complexes. Required for pre-rRNA cleavage at site A2 (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 and U14 snoRNAs. Associates with
CC       pre-ribosomal complexes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX10/DBP4
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR380956; CAG60704.1; -; Genomic_DNA.
DR   RefSeq; XP_447757.1; XM_447757.1.
DR   SMR; Q6FPT7; -.
DR   STRING; 5478.XP_447757.1; -.
DR   PRIDE; Q6FPT7; -.
DR   EnsemblFungi; CAG60704; CAG60704; CAGL0J01045g.
DR   GeneID; 2889849; -.
DR   KEGG; cgr:CAGL0J01045g; -.
DR   CGD; CAL0132906; CAGL0J01045g.
DR   EuPathDB; FungiDB:CAGL0J01045g; -.
DR   eggNOG; KOG0342; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   HOGENOM; HOG000268801; -.
DR   InParanoid; Q6FPT7; -.
DR   KO; K14776; -.
DR   OMA; KVRTKYD; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034512; F:box C/D snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008186; F:RNA-dependent ATPase activity; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    765       ATP-dependent RNA helicase DBP4.
FT                                /FTId=PRO_0000232197.
FT   DOMAIN       72    246       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      274    432       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      85     92       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        41     69       Q motif.
FT   MOTIF       194    197       DEAD box.
SQ   SEQUENCE   765 AA;  87381 MW;  A0FDB5B79E63504B CRC64;
     MAKKHRYTTV QRKQERQKEE EYIKELEQRI QDYDVKNNKA VFFKDLPISK STLKGLNEAS
     FIKMTDIQRD SIVTSLQGHD VFGTAKTGSG KTLAFLVPVL EKLYRERWTE FDGLGALIIS
     PTRELAMQIY EVLVKIGSHT QFSAGLVIGG KDVNFELERI AKINILIGTP GRILQHMDQA
     VGLNTSNLQM LVLDEADRCL DMGFQKTLDA IVGNLPPDRQ TLLFSATQSQ SISDLARLSL
     TDYKKIGTID SSEDGPATPK TLQQSYIIAD LADKLDVLYS FIKSHLKTKM IVFFSSSKQV
     HFVYETFRKM QPGISLLHLH GRQKQRARTE TLDKFFRAQQ VCLFATDVVA RGIDFPAVDW
     VIQVDCPEDV DTYIHRVGRA ARYGKKGRSL IILTPQEEAF LTRMAAKKIE PGKLTIKQSK
     KKSIKPQLQS LLFKDPELKY LGQKAFISYV KSIYIQKDKE VFKFDELPTE EFANSLGLPG
     APRIKIKGMK AIEQAKKLKN TSRSLLSLSK ANDDGEINDK KDKQVRTKYD KMFERKNQTI
     LSEHYLNITK SQAQEDEDED FITVKRKDHE LKEEDLPQLT VPTSRRAQKK ALSKKASLST
     KGNATKMVFD DEGQAHPVYE LEGEEEFHKK GDAEEQKKEF LSKEAEIMAD RDVSDKIIQK
     EKKQEKKRKR LEAMRREMEA AYADEYSDED EEGGNVAYLG TGNLSDDMEE YSSDEESRKT
     KKSKTVDYRF DKKNKTISED TDIMEIQEPE TIEDLESLTA RLIEG
//
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