ID Q6FQA1_CANGA Unreviewed; 3036 AA.
AC Q6FQA1;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Candida glabrata strain CBS138 chromosome I complete sequence {ECO:0000313|EMBL:CAG60530.1};
GN OrderedLocusNames=CAGL0I07909g {ECO:0000313|CGD:CAL0132504,
GN ECO:0000313|EMBL:CAG60530.1};
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593 {ECO:0000313|EMBL:CAG60530.1, ECO:0000313|Proteomes:UP000002428};
RN [1] {ECO:0000313|EMBL:CAG60530.1, ECO:0000313|Proteomes:UP000002428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC {ECO:0000313|Proteomes:UP000002428};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
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DR EMBL; CR380955; CAG60530.1; -; Genomic_DNA.
DR RefSeq; XP_447593.1; XM_447593.1.
DR STRING; 284593.Q6FQA1; -.
DR EnsemblFungi; CAGL0I07909g-T; CAGL0I07909g-T-p1; CAGL0I07909g.
DR GeneID; 2889233; -.
DR KEGG; cgr:CAGL0I07909g; -.
DR CGD; CAL0132504; CAGL0I07909g.
DR VEuPathDB; FungiDB:CAGL0I07909g; -.
DR eggNOG; KOG1826; Eukaryota.
DR HOGENOM; CLU_000439_0_0_1; -.
DR InParanoid; Q6FQA1; -.
DR OMA; WSELMIL; -.
DR Proteomes; UP000002428; Chromosome I.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:EnsemblFungi.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0005096; F:GTPase activator activity; IEA:EnsemblFungi.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:EnsemblFungi.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:EnsemblFungi.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002428}.
FT DOMAIN 1653..1842
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 412..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3036 AA; 347690 MW; 15266C33EDD446D8 CRC64;
MSSDSQPRPY MVGSMVNYLF FSRLLPLLPI ESTATSHVEV EAEPFFISIR GVLMKIAIFK
DLNIVIENAL NLLESILDDE DIISGKIKPD AIQSSLVVVR LLSDIVEFYW QYNEQKSNDK
DDMNTNIDIF EIKSFATPDF DPMARKKSNF DWQKKQQNMS SFFVGYSTSK TCYHQKPPKK
LDGDVISRLI YTCARLTFNT QTLEVLKNIE KHSPEDVHQP NTLDHYDAYL KTNNYPEYCS
NMDNTINHIL KFIAAANPKE YVKFVETNVQ NLLQENALEA EKYIIEYLDL FSYAFITKDF
LPTYLKKVSS VLHSLKNPAY RCLLLFFASE SLLYWIMLRP RDFMGIYSVV EGHHPGSTHL
EVNKTTSVIA NELFEEIYTM FNVSSILSST QSINILNPIR YMERSVSPIP TESNEYRTKS
HRNSFLEREN RGLKSSSPDP LEVHTPAPQF GDVFQDVPTP MSRTSPEITL NASDLIKNYP
ATARNMTSST ASNSSSNSKN FNPFVDFDTI KIQPENTKPE IPHLDNVLDL YTIHDQSIAL
PHTSVLRFLT TLVMIDLDAF TELNSTPSKY LTDIDKLTKG TATSRTSYSK FDSSKQKEKN
GSMKQLSNSW KKLTNLQLSK KKTVKFLKAL IKNLNGLQYV CDNALLDTIG SLLCLMNMNS
ALSLVEPNLP SVLFSRRFLV VLGKNLDVGE NWDGKLNTSM IECLQKYPKV HGRFLLSYFS
SAIRFDYMSF LNHLNLEDAL NSFDLRKLNF YTEGFRIFFH LPNTESLLKA VTEQTSDFIK
ILFSNIADIL LAANAYFGDK VSDIVNSILD GTILDEYGTR KHFTGSTSSD VSSVRSFSPL
QRGFTPGISP SFSEIENSGH LYASAESASP RISDSDSSQT SLENSSQTES QLSHLVAPRP
HHIPPTSSNL RTSVLSSAAV REKSYASSGR NASNEPTANI AAALMTVTTS TPSITSNAMK
SAYQKSKRRY SDEAARRFFR LNMSNVSENA LMDSNSEPNP EAKYIMISIF SIFKTLTKYF
IVPHDQNSKS SWVSKDFRNI IKPIFVAFIS EDDNLQSKAK YFMDVLIEFV TKFSDSTEPL
TMQGYHLICS YTIILFAVGL FDMKLDTKKR ESLLDIVVQF MRVRSHLGIT AEKTNQINII
KDIECATFPM ILGIVGRGLF VSLYCSKPSV QKILKAAFSE FLELLQFHDK YAEQHEKNWI
DNVKFIQAVS GDTHSTSGSV AFQRRVRRSI LNHIKYPDSI LLDSFKMIYR KWYSLSLYTD
YSHEDLNDFR SFAGIIATLS GVLFVGNNSD RENYSYLESM KAELIKDLDY FIAMQCKWLN
DTDLLTRENS KDILSLELHP LSFRFLFKNL RSRLQEIYDL DLSECEQELN FVLLEQIIII
LRTILNREDE EKSMLLFSSE IVDFIDELCC QVEKIPHTSP KYFKGIIQMS KMFRAMKSAE
GTLALMNHYQ LKNKWLKIVT DWFKLTISKN YDFENLSKPH REMDLKTRDL DILHIDTAIE
SSSAIAYLTE NLPLETPAST SSEELKKSQA LVFGHNFNIL FKGLEKTKDP ERFPASLKHK
MNVFTENLIL SLTNLSNRNV EASLQFTLPM GFSKNKNIRL AFLKVFINIV KNSESSQTQS
QKVRLEAMDK LLKFAISHPK LSLVAAAICP ANDLDAYAAD LVDGFNTRNA AHLAVSQLID
AEIEQSTRST DILRRNSVAT RALSMLARLK GNKYLIKTLQ PTLLDLIRNQ EVFEVEKSKP
PGENYERDVA LFKKYMNKIL DSITDSLSYM PPELFYICQG IYQNVKEKFP DYALVAVGSC
MFLRFICPAL VSPESENLVN TISIKEKKSF ISLAKVIQNI ANGSENYVKW ESLKDECQFF
DECKKKIFDF LAEVCRTDRE LKIKIRTDPT PLQFDFGFLH NFLYQNGLAI RKFLLSKDNN
TENFEFLKNT ILLVDSLLGE LGPPRLQYSS GLPDFVRENA TTYPQLYEFM SRYAFKNAHT
LQSATNFVQE SMSAQGIPTL TVLFGNFSSS DLEAEILAYK FLKIYSRIWS AKHYLILDCT
NFHKPRADSK KFTTMLCTLV PDIFVRNCIG FYYFNVNEEF IDMFSIYFRE ENPYLIPEIP
HYFINSSTDD KLVKTLGIGN EGLDIIEDVR ISLHDISLYN EEKKRFTPVL LKMGNRYFQV
LHETPRHYKI DEINSLVSIK FNDVYDISQI SAVHVSSSTG IMKEFTVIFI DGKKLVFSST
KYLEIVKMFS HAQSRLENEY NIASATNNNI RHGGEILSLE KEAESLSENK KIVCHILLVS
LVGLFDDDNL VKNFSYNLLA AAEQSFHLDL GTHFHMSPEI YVPDDTTTFL CVISESLSQN
SPELTRYLWD YILDGLETCL LPHNMIPQTI CALSYWTHNL YEFVFLGHPE EGPEAISRIF
RSLIRLTIAE PDFITIYVQQ IWCLLIIDGR LSDILVEEVI NHALERDSEN RDWSKTIHLL
TALPTVEISS CIIDRLLFKI RGFLPSLRIE ALTQSWSELT ILVKVSVHLF FETPLLAQMF
LPEVLFIISL LIDVGPVELR NSLHGLLMNV CYSLSMNLAL GENERCHLDE ITRIFSTEKS
KFMFGFSQEK GSLLQSFTTT SVSSKFNILE CFITNMMALM DYGATIESGQ WKSRYKKYLM
SFVFNGDSFL SARAIMIVGI VGRNNASLTL CRNLLGETIK VSSIPVVNEE TTFLLIAHIF
CFSKIVDGLH PSSPIIKKMF WFATIFLESK HPILFESGLL LMSMCLRKLY VYRFDDSLEM
GPVIPQLMED RKFADRFLCE IDETYGVSWN ITNFTSIIIS FVIRGFSIPF IRSNALSFLS
MQFKHNYYEH LIDNTSEQFY PYMFLMYLLF GTEQFIEILE DSDYEEKIVY LDQHIRIPMS
LLEWLGKDNE ASQATLFQCA ALFSSTVTDE PFKLRFSLIL EWLLNENPLC VFKFYALIRQ
ELKRISSFER VSDCGPVIFE IVRLLVLHPE FDRLDEFYDS SVKTLKERGL AALTSNENIE
QDTKTLITSL FESPETIFKR KKLTTQIVAV MISSTY
//
