GenomeNet

Database: UniProt
Entry: Q6FR37
LinkDB: Q6FR37
Original site: Q6FR37 
ID   CTM1_CANGA              Reviewed;         551 AA.
AC   Q6FR37;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   10-APR-2019, entry version 68.
DE   RecName: Full=Cytochrome c lysine N-methyltransferase 1;
DE            EC=2.1.1.59;
GN   Name=CTM1; OrderedLocusNames=CAGL0I01210g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Methyltransferase which mediates trimethylation of
CC       cytochrome c (CYC1). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[cytochrome c]-L-lysine + S-adenosyl-L-methionine =
CC         [cytochrome c]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:24312, Rhea:RHEA-COMP:9754,
CC         Rhea:RHEA-COMP:9755, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
CC         EC=2.1.1.59; Evidence={ECO:0000255|PROSITE-ProRule:PRU00943};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- DOMAIN: The SET-like region, although related with the SET domain
CC       is not detected by any prediction method. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190, ECO:0000255|PROSITE-ProRule:PRU00943}.
DR   EMBL; CR380955; CAG60244.1; -; Genomic_DNA.
DR   RefSeq; XP_447307.1; XM_447307.1.
DR   ProteinModelPortal; Q6FR37; -.
DR   STRING; 5478.XP_447307.1; -.
DR   EnsemblFungi; CAG60244; CAG60244; CAGL0I01210g.
DR   GeneID; 2889115; -.
DR   KEGG; cgr:CAGL0I01210g; -.
DR   CGD; CAL0132300; CAGL0I01210g.
DR   EuPathDB; FungiDB:CAGL0I01210g; -.
DR   eggNOG; ENOG410IXGC; Eukaryota.
DR   eggNOG; ENOG410YDYV; LUCA.
DR   InParanoid; Q6FR37; -.
DR   KO; K18804; -.
DR   OMA; IEVETAM; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000277; F:[cytochrome c]-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR025815; Ctm1.
DR   InterPro; IPR001214; SET_dom.
DR   PROSITE; PS51611; SAM_MT59; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    551       Cytochrome c lysine N-methyltransferase
FT                                1.
FT                                /FTId=PRO_0000228982.
FT   DOMAIN       46    273       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   REGION      184    288       SET-like.
SQ   SEQUENCE   551 AA;  63533 MW;  639D2E7A75853C0E CRC64;
     MELANICNAT IAKGIAVQKD SYGGYGVYIV DPGALVGCND PKLGGDKIEL LRVSSVFNVK
     NLMEAMNALE GEYAEDGQRA ADMFKSIIGS SIEELSAVSE TCLLVYFMMV IYLMGEQGYA
     VPMKISRYID TVLLGTTVNN ASNCIESMLI HYEHVALFHE LDNNLQKLHK TLISKMPSKK
     NYSIELLRQI YSATVSRVLE IPQELHEENY MDNYVVTPSL VPILDYVNHG DKTSRNAYYD
     VDRRKGDIIL YLDLTVVNPG KLKPNTEVLI TYKDIEDSLA MITKYGFDPA NYTTTGTKIF
     SCTFDKMYLS TNKFDNEIDI RNFYQWFSIN PSLQFVLNSE NEWLINDSLA EFERLLVPFA
     TSSQRNEHYW IYSDGDDARK RFMEYFDIDE VEDEDEAWAQ LETQFKWFES SENDLMPFPP
     CVWTVKSKFL KEKEATGYEL EKVIQNKLEN SRALYNETTN QFQAYLENYL DYRIDVLQEY
     SPEDTENENA VSQLIARELS VLLKIRDRIN NNKSIFLNSE DKKYAKLPLL PTKNVERPPW
     LSEGDDDFDQ D
//
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