GenomeNet

Database: UniProt
Entry: Q6FW42
LinkDB: Q6FW42
Original site: Q6FW42 
ID   DRS1_CANGA              Reviewed;         725 AA.
AC   Q6FW42;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   16-OCT-2019, entry version 98.
DE   RecName: Full=ATP-dependent RNA helicase DRS1;
DE            EC=3.6.4.13;
GN   Name=DRS1; OrderedLocusNames=CAGL0D03124g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR380950; CAG58463.1; -; Genomic_DNA.
DR   RefSeq; XP_445552.1; XM_445552.1.
DR   SMR; Q6FW42; -.
DR   STRING; 5478.XP_445552.1; -.
DR   PRIDE; Q6FW42; -.
DR   EnsemblFungi; CAG58463; CAG58463; CAGL0D03124g.
DR   GeneID; 2887241; -.
DR   KEGG; cgr:CAGL0D03124g; -.
DR   CGD; CAL0128263; CAGL0D03124g.
DR   EuPathDB; FungiDB:CAGL0D03124g; -.
DR   eggNOG; KOG0338; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   HOGENOM; HOG000265456; -.
DR   InParanoid; Q6FW42; -.
DR   KO; K13181; -.
DR   OMA; HEPERSW; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN         1    725       ATP-dependent RNA helicase DRS1.
FT                                /FTId=PRO_0000232243.
FT   DOMAIN      237    412       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      423    613       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     250    257       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      607    686       {ECO:0000255}.
FT   MOTIF       206    234       Q motif.
FT   MOTIF       360    363       DEAD box.
FT   COMPBIAS    110    203       Glu-rich.
SQ   SEQUENCE   725 AA;  81432 MW;  987B1C6A483780C5 CRC64;
     MSLKMKGKKY TDLDFVPTIS DSEEDVPDLD SDEEKPKPET KGKKKNKSVD EESADMNSGF
     RFNTDDGEIN TNFDGWEFLG DEKDEEKKDV DLDKIIRKKG GLIGMAHVDE AEKSESEESE
     SDDEDLAMDG FGMGAQEQPE GEEEDEDASN SEQESNDEEE DDDEETYDVG DAGDAEEKVE
     EDTAEEMQAF YAPESESENA KKEVHKTFND LALSRPVMKG LSNLGYVKPS PIQSATIPIA
     LLGKDIIAGA VTGSGKTAAF MIPIIERLLY KPAKVASTRV IVLTPTRELA IQVADVGKKI
     GQFVSNLTFG LAVGGLNLRQ QEQMLKTRPD IVIATPGRFI DHIRNSASFN VDSVEVLVID
     EADRMLEDGF QDELNEIMSL LPSKRQTLLF SATMNSRIKQ LISLSLKRPV RIMIDPPKQA
     ATKLTQEFVR IRKRDHLKPS LLFNLIRKLD PNGQKRIVVF VARKDMAHKL RIILGLLGMA
     VAELHGSLTQ EQRLDSVNKF KSLQVPVLIC TDLASRGLDI PKIEVVINYD MPKSYEIYLH
     RVGRTARAGR EGRSITFVGE ASAERSIVKD AIRGVNDSEI PGSKAVGRNV DWNQVEETNK
     IVENMDQTVQ DILVEEKEEK EILRAEMELK KGENLLKHKD EIQSRPKRTW FQSEKEKKNS
     KIMGALSKTK KEVNSKKRKR NEAMEDGHKR SYKKTQSDRT ADQERTMKKQ AKANGKKKGK
     SKGKR
//
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