ID EFEMO_STAAR Reviewed; 284 AA.
AC Q6GJX5;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Efem/EfeO family lipoprotein;
DE Flags: Precursor;
GN OrderedLocusNames=SAR0340;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR EMBL; BX571856; CAG39363.1; -; Genomic_DNA.
DR RefSeq; WP_000737200.1; NC_002952.2.
DR AlphaFoldDB; Q6GJX5; -.
DR SMR; Q6GJX5; -.
DR KEGG; sar:SAR0340; -.
DR HOGENOM; CLU_050342_0_1_9; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14656; Imelysin-like_EfeO; 1.
DR Gene3D; 1.20.1420.20; M75 peptidase, HXXE motif; 1.
DR InterPro; IPR018976; Imelysin-like.
DR InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR InterPro; IPR038352; Imelysin_sf.
DR NCBIfam; NF041757; EfeO; 1.
DR PANTHER; PTHR39192; IRON UPTAKE SYSTEM COMPONENT EFEO; 1.
DR PANTHER; PTHR39192:SF1; IRON UPTAKE SYSTEM COMPONENT EFEO; 1.
DR Pfam; PF09375; Peptidase_M75; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 18..284
FT /note="Efem/EfeO family lipoprotein"
FT /id="PRO_0000278311"
FT LIPID 18
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 18
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 284 AA; 32246 MW; 142CD12CB46BC181 CRC64;
MKKLTTLLLA STLLIAACGN DDSKKDDSKT SKKDDGVKAE LKQATKAYDK YTDEQLNEFL
KGTEKFVKAI ENNDMAQAKA LYPKVRMYYE RSEPVAEAFG DLDPKIDARL ADMKEEKKEK
EWSGYHKIEK ALYEDKKIDD VTKKDAQQLL KNAKELHAKA DTLDITPKLM LQGSVDLLNE
VATSKITGEE EIYSHTDLYD FKANVEGAQK IYDLFKPILE KKDKKLSDDI QMNFDKVNKL
LDKYKDNNGG YESFEKVSKK DRKAFADAVN ALGEPLSKMA VITE
//
