ID Q6GL50_XENTR Unreviewed; 315 AA.
AC Q6GL50; F6Z3J3;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 153.
DE SubName: Full=Secreted frizzled-related protein 5 {ECO:0000313|EMBL:AAH74661.1, ECO:0000313|Ensembl:ENSXETP00000053187, ECO:0000313|RefSeq:NP_001004846.1};
GN Name=sfrp5 {ECO:0000313|EMBL:AAH74661.1,
GN ECO:0000313|Ensembl:ENSXETP00000053187,
GN ECO:0000313|RefSeq:NP_001004846.1,
GN ECO:0000313|Xenbase:XB-GENE-482920};
GN Synonyms=frp5 {ECO:0000313|RefSeq:NP_001004846.1}, sarp3
GN {ECO:0000313|RefSeq:NP_001004846.1}, sFRP-5
GN {ECO:0000313|RefSeq:NP_001004846.1}, sfrp5-a
GN {ECO:0000313|RefSeq:NP_001004846.1}, sfrp5-b
GN {ECO:0000313|RefSeq:NP_001004846.1}, XsFRP5
GN {ECO:0000313|RefSeq:NP_001004846.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH74661.1};
RN [1] {ECO:0000313|RefSeq:NP_001004846.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH74661.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH74661.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000053187}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000053187};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000053187}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001004846.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26631720;
RA Nakamura K., Sano S., Fuster J.J., Kikuchi R., Shimizu I., Ohshima K.,
RA Katanasaka Y., Ouchi N., Walsh K.;
RT "Secreted Frizzled-related Protein 5 Diminishes Cardiac Inflammation and
RT Protects the Heart from Ischemia/Reperfusion Injury.";
RL J. Biol. Chem. 291:2566-2575(2016).
RN [6] {ECO:0000313|RefSeq:NP_001004846.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; BC074661; AAH74661.1; -; mRNA.
DR RefSeq; NP_001004846.1; NM_001004846.1.
DR STRING; 8364.ENSXETP00000008606; -.
DR MEROPS; I93.002; -.
DR PaxDb; 8364-ENSXETP00000039854; -.
DR PaxDb; 8364-ENSXETP00000053187; -.
DR DNASU; 448129; -.
DR Ensembl; ENSXETT00000053187; ENSXETP00000053187; ENSXETG00000024699.
DR GeneID; 448129; -.
DR KEGG; xtr:448129; -.
DR AGR; Xenbase:XB-GENE-482920; -.
DR CTD; 6425; -.
DR Xenbase; XB-GENE-482920; sfrp5.
DR eggNOG; KOG3577; Eukaryota.
DR HOGENOM; CLU_054647_0_0_1; -.
DR OMA; GGQHYDY; -.
DR OrthoDB; 4814466at2759; -.
DR TreeFam; TF350133; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000024699; Expressed in heart and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd07444; CRD_SFRP5; 1.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR041761; SFRP5_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF46; SECRETED FRIZZLED-RELATED PROTEIN 5; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001004846.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..315
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001004846.1"
FT /id="PRO_5033205991"
FT DOMAIN 44..161
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 177..299
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 59..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 124..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 315 AA; 36456 MW; 9DB8E9112FB3A386 CRC64;
MRFQWNILAW VNSLILGLVL WSSAEEYDYY SWQSDNFQNG RFYTKQSQCI DIPSDLHLCH
NVGYKKMRLP NLLDHETMPE VKQQASSWVP LLAKRCHRDT QLFLCSLFAP ICLERPIYPC
RSLCEVVRDS CAPVMESYGF PWPEMLNCNK FPLDNDLCIT VQFGSKQVTQ PPVTKICTQC
EIEQKSETMR VQLCASDFVL RMRIKEVKIE NGDRKLIAAQ KKKKVLKAGK LKRKEFRKLV
LYIKNAASCP CPQLDNLSGS FLIMGRKVDN KLLLTAIYKW DKKSKDMKYA VNFMYSYPCS
DTISHGTGSH LGSFR
//
