ID EMX1_XENTR Reviewed; 233 AA.
AC Q6GLB9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Homeobox protein EMX1;
DE AltName: Full=Empty spiracles homolog 1;
DE AltName: Full=Empty spiracles-like protein 1;
GN Name=emx1; ORFNames=TNeu052k18.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function in combinations with OTX1/2 to specify cell
CC fates in the developing central nervous system. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; CR760018; CAJ82390.1; -; mRNA.
DR EMBL; BC074580; AAH74580.1; -; mRNA.
DR RefSeq; NP_001005459.1; NM_001005459.1.
DR AlphaFoldDB; Q6GLB9; -.
DR SMR; Q6GLB9; -.
DR STRING; 8364.ENSXETP00000018669; -.
DR PaxDb; 8364-ENSXETP00000038936; -.
DR DNASU; 448058; -.
DR Ensembl; ENSXETT00000123072; ENSXETP00000105323; ENSXETG00000048254.
DR GeneID; 448058; -.
DR KEGG; xtr:448058; -.
DR AGR; Xenbase:XB-GENE-920144; -.
DR CTD; 2016; -.
DR Xenbase; XB-GENE-920144; emx1.
DR eggNOG; KOG0843; Eukaryota.
DR HOGENOM; CLU_1900878_0_0_1; -.
DR InParanoid; Q6GLB9; -.
DR OMA; MNGYQAP; -.
DR OrthoDB; 903523at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24339; HOMEOBOX PROTEIN EMX-RELATED; 1.
DR PANTHER; PTHR24339:SF26; HOMEOBOX PROTEIN EMX1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..233
FT /note="Homeobox protein EMX1"
FT /id="PRO_0000270144"
FT DNA_BIND 135..194
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 192..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 26545 MW; B7005300AF432684 CRC64;
MFQPAGKRCF TIESLVAKDN PLSSEEPLRP AALPYPGAPA EAFVSGFPSP AGRSLYNNPE
LVFPETVSHP PLTVHPHQLG ASHLQHPHSF FAPQHRDPLN FYPWVLRNRF FGHRFQGGDV
SQESLLLHGP FARKPKRIRT AFSPSQLLRL ERAFEKNHYV VGAERKQLAS SLSLSETQVK
VWFQNRRTKY KRQKLEEEGP DSDQKKKGSH HINRWRLATK QPNGEDIDVT SND
//
