ID Q6GLI5_XENTR Unreviewed; 201 AA.
AC Q6GLI5;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=BCL2-like 1 {ECO:0000313|EMBL:AAH74505.1, ECO:0000313|Ensembl:ENSXETP00000116155};
GN Name=bcl2l1 {ECO:0000313|EMBL:AAH74505.1,
GN ECO:0000313|Ensembl:ENSXETP00000116155,
GN ECO:0000313|RefSeq:NP_001005428.1,
GN ECO:0000313|Xenbase:XB-GENE-481317};
GN Synonyms=bcl-x {ECO:0000313|RefSeq:NP_001005428.1}, bcl-x(l)
GN {ECO:0000313|RefSeq:NP_001005428.1}, bcl-XL
GN {ECO:0000313|RefSeq:NP_001005428.1}, bcl-xl/s
GN {ECO:0000313|RefSeq:NP_001005428.1}, bcl-xs
GN {ECO:0000313|RefSeq:NP_001005428.1}, bcl2l
GN {ECO:0000313|RefSeq:NP_001005428.1}, bclx
GN {ECO:0000313|RefSeq:NP_001005428.1}, bclxl
GN {ECO:0000313|RefSeq:NP_001005428.1}, xR11
GN {ECO:0000313|RefSeq:NP_001005428.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH74505.1};
RN [1] {ECO:0000313|RefSeq:NP_001005428.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH74505.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH74505.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000116155}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000116155};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000116155}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001005428.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; BC074505; AAH74505.1; -; mRNA.
DR RefSeq; NP_001005428.1; NM_001005428.1.
DR DNASU; 447991; -.
DR Ensembl; ENSXETT00000116615; ENSXETP00000116155; ENSXETG00000043454.
DR GeneID; 447991; -.
DR KEGG; xtr:447991; -.
DR CTD; 598; -.
DR Xenbase; XB-GENE-481317; bcl2l1.
DR eggNOG; KOG4728; Eukaryota.
DR HOGENOM; CLU_085401_0_0_1; -.
DR OMA; RIIEWMT; -.
DR OrthoDB; 4028889at2759; -.
DR TreeFam; TF315834; -.
DR Reactome; R-XTR-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
DR Reactome; R-XTR-9648002; RAS processing.
DR Proteomes; UP000008143; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR013279; Apop_reg_BclX.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR InterPro; IPR003093; Bcl2_BH4.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF12; BCL-2-LIKE PROTEIN 1; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01864; APOPREGBCLX.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SMART; SM00265; BH4; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01080; BH1; 1.
DR PROSITE; PS01258; BH2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..26
FT /note="Apoptosis regulator Bcl-2 family BH4"
FT /evidence="ECO:0000259|SMART:SM00265"
FT DOMAIN 58..156
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
FT REGION 22..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 201 AA; 22335 MW; EEFF0B533BBF7EA5 CRC64;
MEGSSRDLVE KFVCKKLSQK GACGEFSSNS QPKGVSNGSS EGPGATQGIV GEEVLQALLD
ASEEFELRYQ RAFSDLTAQL HLTQDTAQQS FQQVVGELFR DGTNWGRIVA FFSFGRALCV
ESANKEMTEL LPRIVQWMVQ YLEHTLQPWM LENGGWEAFV GLYGKGAAAQ SREGPERFGR
WLMAIVTVTA ATLLVSYLRR R
//
