ID Q6GMI6_DANRE Unreviewed; 258 AA.
AC Q6GMI6; A0A2R8Q2I1; F6P9C5;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 140.
DE SubName: Full=BTB/POZ domain-containing protein KCTD4 {ECO:0000313|RefSeq:NP_001002224.1};
DE SubName: Full=Potassium channel tetramerization domain-containing 4 {ECO:0000313|Ensembl:ENSDARP00000090220};
DE SubName: Full=Zgc:92463 {ECO:0000313|EMBL:AAI53448.1};
GN Name=kctd4 {ECO:0000313|Ensembl:ENSDARP00000090220,
GN ECO:0000313|RefSeq:NP_001002224.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040704-71};
GN Synonyms=wu:fk37b10 {ECO:0000313|RefSeq:NP_001002224.1};
GN ORFNames=zgc:92463 {ECO:0000313|EMBL:AAI53448.1,
GN ECO:0000313|RefSeq:NP_001002224.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI53448.1};
RN [1] {ECO:0000313|EMBL:AAI53448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mixed tissue {ECO:0000313|EMBL:AAI53448.1}, and Whole
RC {ECO:0000313|EMBL:AAH74061.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001002224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001002224.1};
RX PubMed=19166982; DOI=10.1016/j.gep.2008.12.007;
RA Toro S., Wegner J., Muller M., Westerfield M., Varga Z.M.;
RT "Identification of differentially expressed genes in the zebrafish
RT hypothalamic-pituitary axis.";
RL Gene Expr. Patterns 9:200-208(2009).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000090220}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090220};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000090220, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090220};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001002224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001002224.1};
RX PubMed=27615194;
RA Takeuchi M., Yamaguchi S., Sakakibara Y., Hayashi T., Matsuda K., Hara Y.,
RA Tanegashima C., Shimizu T., Kuraku S., Hibi M.;
RT "Gene expression profiling of granule cells and Purkinje cells in the
RT zebrafish cerebellum.";
RL J. Comp. Neurol. 525:1558-1585(2017).
RN [6] {ECO:0000313|RefSeq:NP_001002224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001002224.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000148033}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000148033};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001002224.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001002224.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX897687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR954294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074061; AAH74061.1; -; mRNA.
DR EMBL; BC153447; AAI53448.1; -; mRNA.
DR RefSeq; NP_001002224.1; NM_001002224.2.
DR STRING; 7955.ENSDARP00000090220; -.
DR PaxDb; 7955-ENSDARP00000090220; -.
DR Ensembl; ENSDART00000099446.5; ENSDARP00000090220.3; ENSDARG00000068691.5.
DR Ensembl; ENSDART00000189575.1; ENSDARP00000148033.1; ENSDARG00000116087.1.
DR GeneID; 792402; -.
DR KEGG; dre:792402; -.
DR AGR; ZFIN:ZDB-GENE-040704-71; -.
DR CTD; 386618; -.
DR ZFIN; ZDB-GENE-040704-71; kctd4.
DR eggNOG; KOG2723; Eukaryota.
DR HOGENOM; CLU_1081647_0_0_1; -.
DR OMA; GKKPVQH; -.
DR OrthoDB; 2912088at2759; -.
DR TreeFam; TF315332; -.
DR Proteomes; UP000000437; Alternate scaffold 9.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000068691; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18364; BTB_POZ_KCTD4; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR045740; KCTD4_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF9; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD4; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF19323; KCTD4_C; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 32..134
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
SQ SEQUENCE 258 AA; 29660 MW; 80043A76EE734B78 CRC64;
MEWNLRRMES ELRQINPDLL QPSKSFKKPS SGTITINVGG YLYAAQRHTL AKHPGSLLEE
MVTGKKPVLH VDSMGNTFID RDGPIFRHIL NFLRLGELVL PEDFKETELL RREANFYRLS
ELAQALQDWE QQQATQREPA FLEVTDSHER SQGLRVYCSD NTFIEKVKNR LVQISKSRLD
GFPEEFEVSS NIIQFRHFIK SEQGSRLVLK QDSTFLCTLE CLKLETVMLA LKGGFRLITS
LDSSRGSVVQ CEALHFVK
//
