UniProt: Q6GNR1

Database: UniProt
Entry: Q6GNR1_XENLA

LinkDB:  Q6GNR1_XENLA 
Original site:  Q6GNR1_XENLA

All links

Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   XENBASE (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (4)   
   Pfam (1)   
   PROSITE (3)   
   SMART (4)   
Literature (1)   
   PubMed (1)   
All databases (25)   

Download RDF

ID   Q6GNR1_XENLA            Unreviewed;       221 AA.
AC   Q6GNR1;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 113.
DE   RecName: Full=Ras-related protein Rab-27A {ECO:0000256|ARBA:ARBA00039763};
DE            EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
GN   Name=rab27a.L {ECO:0000313|RefSeq:NP_001085863.1,
GN   ECO:0000313|RefSeq:XP_018106448.1, ECO:0000313|RefSeq:XP_041441022.1,
GN   ECO:0000313|Xenbase:XB-GENE-865978};
GN   Synonyms=gs2 {ECO:0000313|RefSeq:NP_001085863.1,
GN   ECO:0000313|RefSeq:XP_018106448.1, ECO:0000313|RefSeq:XP_041441022.1},
GN   MGC80943 {ECO:0000313|EMBL:AAH73442.1}, rab27
GN   {ECO:0000313|RefSeq:NP_001085863.1, ECO:0000313|RefSeq:XP_018106448.1,
GN   ECO:0000313|RefSeq:XP_041441022.1}, rab27a
GN   {ECO:0000313|RefSeq:XP_018106448.1}, rab27a-a
GN   {ECO:0000313|RefSeq:NP_001085863.1, ECO:0000313|RefSeq:XP_018106448.1,
GN   ECO:0000313|RefSeq:XP_041441022.1}, rab27a-b
GN   {ECO:0000313|RefSeq:XP_018106448.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH73442.1};
RN   [1] {ECO:0000313|RefSeq:NP_001085863.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH73442.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH73442.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001085863.1, ECO:0000313|RefSeq:XP_018106448.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018106448.1,
RC   ECO:0000313|RefSeq:XP_041441022.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018106448.1,
RC   ECO:0000313|RefSeq:XP_041441022.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000249};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00000249};
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000256|ARBA:ARBA00004177}. Late
CC       endosome {ECO:0000256|ARBA:ARBA00004603}. Lysosome
CC       {ECO:0000256|ARBA:ARBA00004371}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000256|ARBA:ARBA00006270}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC073442; AAH73442.1; -; mRNA.
DR   RefSeq; NP_001085863.1; NM_001092394.1.
DR   RefSeq; XP_018106448.1; XM_018250959.2.
DR   RefSeq; XP_041441022.1; XM_041585088.1.
DR   STRING; 8355.Q6GNR1; -.
DR   PaxDb; 8355-Q6GNR1; -.
DR   DNASU; 444290; -.
DR   GeneID; 444290; -.
DR   KEGG; xla:444290; -.
DR   AGR; Xenbase:XB-GENE-865978; -.
DR   CTD; 444290; -.
DR   Xenbase; XB-GENE-865978; rab27a.L.
DR   OMA; RMERCMD; -.
DR   OrthoDB; 8685at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 444290; Expressed in stomach and 19 other cell types or tissues.
DR   GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   CDD; cd04127; Rab27A; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041837; Rab27a/b.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR   PANTHER; PTHR47977:SF20; RAS-RELATED PROTEIN RAB-27A; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ   SEQUENCE   221 AA;  25138 MW;  A9A8EF4274DDFE45 CRC64;
     MSDGDYDYLI KFLALGDSAV GKTSFLYQYT DGKFNSKFIT TVGIDFREKR VVYRSNGPDG
     TSGRGQRVHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWMSQLQIH
     AYCENPDIVL CGNKCDLDDQ RAVKEEEAKE FAEKYGIPYF ETSAANGTNV NKAVDTLLDL
     IMKRMERCVD KSWIPQGVVQ SNGHRSTEQL TEEKDKGKCG C
//

DBGET integrated database retrieval system