ID Q6GQ43_XENLA Unreviewed; 722 AA.
AC Q6GQ43;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0000256|ARBA:ARBA00013911};
DE AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha {ECO:0000256|ARBA:ARBA00031433};
GN Name=pik3r1.L {ECO:0000313|RefSeq:NP_001085538.1,
GN ECO:0000313|Xenbase:XB-GENE-6067242};
GN Synonyms=grb1 {ECO:0000313|RefSeq:NP_001085538.1}, MGC80357
GN {ECO:0000313|EMBL:AAH72905.1}, p85-alpha
GN {ECO:0000313|RefSeq:NP_001085538.1}, pik3r1
GN {ECO:0000313|RefSeq:NP_001085538.1,
GN ECO:0000313|Xenbase:XB-GENE-6067242}, pik3r1-a
GN {ECO:0000313|RefSeq:NP_001085538.1}, pik3r1-b
GN {ECO:0000313|RefSeq:NP_001085538.1}, pik3r1.S
GN {ECO:0000313|RefSeq:NP_001085538.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH72905.1};
RN [1] {ECO:0000313|RefSeq:NP_001085538.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH72905.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000313|EMBL:AAH72905.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085538.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; BC072905; AAH72905.1; -; mRNA.
DR RefSeq; NP_001085538.1; NM_001092069.1.
DR STRING; 8355.Q6GQ43; -.
DR PaxDb; 8355-Q6GQ43; -.
DR DNASU; 443964; -.
DR GeneID; 443964; -.
DR KEGG; xla:443964; -.
DR AGR; Xenbase:XB-GENE-6067242; -.
DR Xenbase; XB-GENE-6067242; pik3r1.L.
DR OMA; GNENTEX; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 443964; Expressed in kidney and 19 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd04388; RhoGAP_p85; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR CDD; cd11910; SH3_PI3K_p85alpha; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035591; PI3K_p85alpha_SH3.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..80
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 112..300
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 332..427
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 622..716
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 80..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 441..468
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 527..561
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 85..99
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 83128 MW; E63EEA55D2B06D79 CRC64;
MSGEGYQYRA LYPYKKEREE DIDLRVGDIL TVSRATLLPL GCYAEGMEAR PEQIGWLNGC
NENTGQRGDF PGTYVEYLGR KRISPPTPKP RPPRPLPVAP GAARGESETQ AFTLPDLTEQ
FSPPDTAPPL LIKLIEAIEK KGLESATLYR SQSSSSLTEL RQILEYDAAS VDFEQFDIAI
LSDALKRYLL DLPNPVIPAL MYSEMLSAAR ESISSEEYVQ LLRKIIRCAN VPQHYWLTLQ
YLLKHFFQLC QSASKNLLSA KSLAEIFSPL LFRIQVSSSD GSEFSTQILE VLITSEWNEK
QAAPALPPKP PKSTAVTNNG TNHIMSLQDA EWYWGDISRE EVNEKLRDTT DGTFLVRDAS
TIMHGDYTLT LRKGGNNKLI KIFHRDGKYG FSDPLTFNSV VELITHYRNE SLAQYNPKLD
VKLLYPVSKL QQDQVVKEDS IEAVGKKLRE YNVQFQEKNQ EYDRLYEDYT RTSQEIQMKR
TAIEAFNETI KIFEEQCQTQ EKYSKEYIEK FRREGNEKEI QRILHNHEKL KSRISEIVDS
KRRLEEDLKK QTAENREIDK RMNSIKPDLI QLRKTRDQYL MWLTQKGVRQ KKLNEWLGSD
NTEDQYSVVE DEDLPHQDER TWNVGNINRN QAENLLRGKR DGTFLVRESS KAGCYACSVM
ADGEVKHCVI NKTHTGFGFA EPYNLYSSLK ELVLHYQQTS LVQHNDSLNV TLAHPVYAQQ
RR
//
