ID   MID49_XENLA             Reviewed;         463 AA.
AC   Q6GQ81;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Mitochondrial dynamics protein MID49;
DE   AltName: Full=Mitochondrial dynamics protein of 49 kDa homolog;
DE   AltName: Full=Mitochondrial elongation factor 2;
DE   AltName: Full=Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog;
GN   Name=mief2; Synonyms=mid49, smcr7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial outer membrane protein which regulates
CC       mitochondrial organization (By similarity). It is required for
CC       mitochondrial fission and promotes the recruitment and association of
CC       the fission mediator dynamin-related protein 1 (DNM1L) to the
CC       mitochondrial surface independently of the mitochondrial fission FIS1
CC       and MFF proteins (By similarity). Regulates DNM1L GTPase activity (By
CC       similarity). {ECO:0000250|UniProtKB:Q96C03}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: Does not bind ADP or other nucleotides, in contrast to
CC       MIEF1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MID49/MID51 family. {ECO:0000305}.
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DR   EMBL; BC072866; AAH72866.1; -; mRNA.
DR   RefSeq; NP_001085509.1; NM_001092040.1.
DR   AlphaFoldDB; Q6GQ81; -.
DR   SMR; Q6GQ81; -.
DR   DNASU; 443935; -.
DR   GeneID; 443935; -.
DR   KEGG; xla:443935; -.
DR   AGR; Xenbase:XB-GENE-977726; -.
DR   CTD; 443935; -.
DR   Xenbase; XB-GENE-977726; mief2.S.
DR   OrthoDB; 2897585at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 443935; Expressed in ovary and 19 other cell types or tissues.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   GO; GO:0090141; P:positive regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
DR   Gene3D; 1.10.1410.40; -; 1.
DR   Gene3D; 3.30.460.90; -; 1.
DR   InterPro; IPR024810; Mab-21-like.
DR   InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR   InterPro; IPR045909; MID49/MID51.
DR   InterPro; IPR049097; MID51-like_C.
DR   PANTHER; PTHR16451:SF11; MITOCHONDRIAL DYNAMICS PROTEIN MID49; 1.
DR   PANTHER; PTHR16451; MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER; 1.
DR   Pfam; PF20266; Mab-21_C; 1.
DR   Pfam; PF21297; MID51-like_C; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..463
FT                   /note="Mitochondrial dynamics protein MID49"
FT                   /id="PRO_0000310454"
FT   TOPO_DOM        1..24
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..463
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          87..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  51991 MW;  4D7C50BE4D17D6AF CRC64;
     MAELQIRKKE KKSGDGIGTM VDFLLANARL VLGVGGAAML GIATLAVKRL IDRATSPPSD
     KEAEEKAEQK SIEESWKEAV LKKASPTLRR KEDLEHHCAP LSLPDPSQKM PEATGTSQVK
     ASDEIKKIPI CFTLQERLLN YHTHHASVPE VQMEEARQLV LDIKKELQEF LHAKHPEMPF
     LALHLGGSFG NRLPMSCLDH ACLIMPLVLE PDLWCVIPGQ KTILSDPNFC MVKRIDLEYT
     SRGSSPWDRF LVGAYLSSRT MVQSLHKTIV GSINWPAIGT VLDCTIKPDI TSDELKLEVV
     HPNGHMIIRI LPMAVIKDAD LLAHCCATAP AENLWQRSFY KKEVSRLQEL DSSDSGIRLK
     CLQILKGICR DCPSLCHLNS THLRHILLHL STESSDWTET ALADRFLQVL EELIGYLDKG
     FLPSYFNDKL NLFSSLKAED IEELGYGLYQ VFSEPDDVLK RER
//