ID EDRF1_MOUSE Reviewed; 1239 AA.
AC Q6GQV7; Q80ZY3; Q8R3P5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE RecName: Full=Erythroid differentiation-related factor 1;
GN Name=Edrf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Fetal brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transcription factor involved in erythroid differentiation.
CC Involved in transcriptional activation of the globin gene (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24916.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH46235.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC024916; AAH24916.1; ALT_INIT; mRNA.
DR EMBL; BC046235; AAH46235.1; ALT_INIT; mRNA.
DR EMBL; BC072596; AAH72596.1; -; mRNA.
DR RefSeq; NP_835216.3; NM_178115.4.
DR AlphaFoldDB; Q6GQV7; -.
DR BioGRID; 229562; 2.
DR STRING; 10090.ENSMUSP00000059166; -.
DR iPTMnet; Q6GQV7; -.
DR PhosphoSitePlus; Q6GQV7; -.
DR EPD; Q6GQV7; -.
DR MaxQB; Q6GQV7; -.
DR PaxDb; 10090-ENSMUSP00000059166; -.
DR ProteomicsDB; 277684; -.
DR Pumba; Q6GQV7; -.
DR GeneID; 214764; -.
DR KEGG; mmu:214764; -.
DR AGR; MGI:1919831; -.
DR CTD; 26098; -.
DR MGI; MGI:1919831; Edrf1.
DR eggNOG; ENOG502QTNC; Eukaryota.
DR InParanoid; Q6GQV7; -.
DR OMA; AFLYCNM; -.
DR OrthoDB; 38376at2759; -.
DR PhylomeDB; Q6GQV7; -.
DR BioGRID-ORCS; 214764; 11 hits in 78 CRISPR screens.
DR ChiTaRS; Edrf1; mouse.
DR PRO; PR:Q6GQV7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6GQV7; Protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:MGI.
DR PANTHER; PTHR15000; ERYTHROID DIFFERENTIATION-RELATED FACTOR 1; 1.
DR PANTHER; PTHR15000:SF1; ERYTHROID DIFFERENTIATION-RELATED FACTOR 1; 1.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Reference proteome; Repeat; TPR repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..1239
FT /note="Erythroid differentiation-related factor 1"
FT /id="PRO_0000244261"
FT REPEAT 693..726
FT /note="TPR 1"
FT REPEAT 914..953
FT /note="TPR 2"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..546
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1239 AA; 138834 MW; 53C896457CF75797 CRC64;
MGDPKEAGAE ASPSGAAARG GLSLLSQADS EEPSAQGSAL FLGGNEVKSR AVVKYSSAPP
RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK SKPFSSFGMA YDFIDSVGND
VDVVSDSENI KKLLKIPYSK SHVSMAVHRI GRTLLLDELD IQELFMRSSQ TGDWTWLKEF
YQRLIDQKWQ RKKKSKEHWY QKAILSKFLY YSINGDGAAQ PVPSPAEQEE SSSSQQTHES
EGAAWPAPFE MPSSVSEDPS ASSQGREPLE PSCIVGHVAS APKEQNLTTL FNDGENSQGL
KNDFVRNILW TFEDIHMLVG SNMPIFGGGR YPAVSLRLRD NNKPINVLTG IDYWLDNLIC
NVPELVMCFH VNGIVQKYEM IKTEEIPNLE NSNFSTKVIK DIAQNILSFL KSNCTKEGHT
YWLFKASGSD IVKLYDLTTL CEETEDKYQN PFTMPVAILL YKVACNMMMK KNQNKKHYGT
IRTLLLNCVK LLDKSRHPQI IASANYMLSE LFQLDEPKKE ESSDSPLNEN SDESYSEEEE
EMADSDENGS YSTSSDPADD NKAVAIIKSV GELSVPEKYK SIHQIRPSCA FPVCHDTEER
CRLVLSYVLE GLKSVDSSIK KESDLPAADP STPIPLKYED ESTRGGPEGL EKQMALFLDK
MGSIQKGSCS GQSGMTPGSW QHKMKLQLIL KSSKAYYILS DAAMSLQKYG RALRYIKLAL
QSHDTYCCLC TNMLSEVLLF LSQYLTLCGD IQLMLAQNAN NRAAHLEEFN YQTKEDQEIL
HSLHRESSCQ GFAWATDLST DLESQLSVSC KCYEAANEIL QFSDLKSQNP EHYVQVLKRM
GNIRNEIGVF YMNQAAALQG ERVVSKSVSA AEQQLWKKSF SCFEKGIHNF ESIDDATNAA
LLLCNTGRLM RVCAQAHCGA EDEFKREFSP EEGLYYSKAV DYYLKALRSL GTRDMHPIVW
DSVNWELSTT YFTMATLQQD YAPLSRKAQE QIEKEVSEAM MKSLKHCDVD SATARQPLCQ
YRAATIHHRL ASMYHSCLRN QVGDEHLRKQ HRVLADLHYS KAAKLFQLLK DAPCELLRVQ
LERVAFAEFQ MSSQNSNVGK LKTLSGALDI MVRTEHAFQL IRKELVEECD QPKNDEATPA
ADSSPNLNRE EVIKLLSIFE SRLSFLLLQS IKLMSSSKRK MSSNAEEDIV LQTNKQIYSQ
LLRATANRNS TLLERIEVVI CLLEQLASGS SRSSGSAVP
//
