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Database: UniProt
Entry: Q6GVM6
LinkDB: Q6GVM6
Original site: Q6GVM6 
ID   DDX3Y_PANTR             Reviewed;         660 AA.
AC   Q6GVM6;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   16-OCT-2019, entry version 117.
DE   RecName: Full=ATP-dependent RNA helicase DDX3Y;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 3, Y-chromosomal;
GN   Name=DDX3Y;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hughes J.F., Pyntikova T., Skaletsky H., Minx P.J., Rozen S.,
RA   Wilson R.K., Page D.C.;
RT   "The DNA sequence of the chimpanzee Y chromosome.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable ATP-dependent RNA helicase. May play a role in
CC       spermatogenesis (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: May interact with TDRD3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm
CC       in an XPO1-dependent manner. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AY633112; AAT46349.1; -; mRNA.
DR   RefSeq; NP_001008986.1; NM_001008986.1.
DR   RefSeq; XP_016800148.1; XM_016944659.1.
DR   SMR; Q6GVM6; -.
DR   STRING; 9598.ENSPTRP00000038771; -.
DR   PaxDb; Q6GVM6; -.
DR   PRIDE; Q6GVM6; -.
DR   Ensembl; ENSPTRT00000041996; ENSPTRP00000038771; ENSPTRG00000022488.
DR   GeneID; 449508; -.
DR   KEGG; ptr:449508; -.
DR   CTD; 8653; -.
DR   VGNC; VGNC:13341; DDX3Y.
DR   eggNOG; KOG0335; Eukaryota.
DR   eggNOG; ENOG410XNTI; LUCA.
DR   GeneTree; ENSGT00940000154443; -.
DR   HOGENOM; HOG000268804; -.
DR   InParanoid; Q6GVM6; -.
DR   KO; K17642; -.
DR   OrthoDB; 595675at2759; -.
DR   TreeFam; TF300364; -.
DR   Proteomes; UP000002277; Chromosome Y.
DR   Bgee; ENSPTRG00000022488; Expressed in 6 organ(s), highest expression level in testis.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043186; C:P granule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007276; P:gamete generation; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Complete proteome; Cytoplasm; DNA-binding;
KW   Helicase; Hydrolase; Isopeptide bond; Methylation; Nucleotide-binding;
KW   Nucleus; Phosphoprotein; Reference proteome; RNA-binding;
KW   Ubl conjugation.
FT   INIT_MET      1      1       Removed. {ECO:0000250|UniProtKB:O00571}.
FT   CHAIN         2    660       ATP-dependent RNA helicase DDX3Y.
FT                                /FTId=PRO_0000055013.
FT   DOMAIN      209    401       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      412    573       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     198    205       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   NP_BIND     222    229       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       178    206       Q motif.
FT   MOTIF       345    348       DEAD box.
FT   MOD_RES       2      2       N-acetylserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES      55     55       N6-acetyllysine.
FT                                {ECO:0000250|UniProtKB:Q62167}.
FT   MOD_RES      85     85       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES      89     89       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     100    100       Omega-N-methylarginine.
FT                                {ECO:0000250|UniProtKB:Q62167}.
FT   MOD_RES     101    101       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     103    103       Phosphotyrosine.
FT                                {ECO:0000250|UniProtKB:Q62167}.
FT   MOD_RES     109    109       Omega-N-methylarginine.
FT                                {ECO:0000250|UniProtKB:Q62167}.
FT   MOD_RES     129    129       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     454    454       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q62095}.
FT   MOD_RES     590    590       Omega-N-methylarginine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     592    592       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     603    603       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     615    615       Omega-N-methylarginine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   MOD_RES     630    630       Omega-N-methylarginine.
FT                                {ECO:0000250|UniProtKB:O00571}.
FT   CROSSLNK    213    213       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:O00571}.
SQ   SEQUENCE   660 AA;  73191 MW;  B84FDEC14235AC74 CRC64;
     MSHVVVKNDP ELDQQLANLD LNSEKQSGGA SRASKGRYIP PHLRNREASK GFHDKDSSGW
     SCSKDKDAYN SFGSRDSRGK PGYFSERGSG SRGRFDDRGR SDYDGIGNRD RPGFGRFERN
     GHSRWCDKSD EDDWSKPLPP SERLEQELFS GGNTGINFEK YDDIPVEATG SNCPPHIENF
     GDIDMGEIIM GNIQLTRYTR PTPVQKHAIP IIKGKRDLMA CAQTGSGKTA AFLLPILSQI
     YTDGPGEALK AVKENGRYGR RKQYPISLVL APTRELAVQI YEEARKFSYR SRVRPCVVYG
     GADIGQQIRD LERGCHLLVA TPGRLVDMME RGKIGLDFCK YLVLDEADRM LDMGFEPQIR
     RIVEQDTMPP KGVRHTMMFS ATFPKEIQML ARDFLDEYIF LAVGRVGSTS ENITQKVVWV
     EDLDKRSFLL DILGAAGTDS LTLVFVETKK GADSLEDFLY HEGYACTSIH GDRSQRDREE
     ALHQFRSGKS PILVATAVAA RGLDISNVRH VINFDLPSDI EEYVHRIGRT GRVGNLGLAT
     SFFNEKNINI TKDLLDLLVE AKQEVPSWLE NMAYEHQYKG GSRGRSKSNR FSGGFGARDY
     RQSSGSSSSG FGASRGSSSR SGGGGYGNSR GFGGGGYGGF YNSDGYGGNY NSQGVDWWGN
//
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