ID 019R_FRG3G Reviewed; 851 AA.
AC Q6GZV6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=Putative serine/threonine-protein kinase 019R;
DE EC=2.7.11.1;
GN ORFNames=FV3-019R;
OS Frog virus 3 (isolate Goorha) (FV-3).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus; Frog virus 3.
OX NCBI_TaxID=654924;
OH NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT "Comparative genomic analyses of frog virus 3, type species of the genus
RT Ranavirus (family Iridoviridae).";
RL Virology 323:70-84(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AY548484; AAT09678.1; -; Genomic_DNA.
DR RefSeq; YP_031597.1; NC_005946.1.
DR GeneID; 2947739; -.
DR KEGG; vg:2947739; -.
DR Proteomes; UP000008770; Segment.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR014901; 2-cysteine_adaptor.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF08793; 2C_adapt; 5.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..851
FT /note="Putative serine/threonine-protein kinase 019R"
FT /id="PRO_0000410576"
FT DOMAIN 456..851
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..212
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 608
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 462..470
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 485
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 851 AA; 92929 MW; 5FB497EDDDD37D89 CRC64;
MATNYCDEFE RNPTRNPRTG RTIKRGGPVF RALERECSDG AARVFPAAAV RGAAAARAAS
PRVAAASPCP EFARDPTRNP RTGRPIKRGG PVFRALEREC ADYGGASPRR VSPARAFPNR
RVSPARRQSP AEAAEASPCP EFARDPTRNP RTGRTIKRGG PTYRALEAEC ADYGRLSPIR
SPWSDWSSTG LSPFRSHMRK SPARRSPARR SPARRSLARY TEHLTSDSET EVDYDARNVI
RSQVGPGGVC ERFAADPTRN PVTGSPLSRN DPLYTDLMEI CKGYPDTPLT KSLTGEGTDD
DTCEAFCRDP TRNPVTGQKM RRNGIEYQMF AEECDCSGIS RPSGVSRTSG TSGSSGSSAS
SRPPNSFEAP GASSRPPNSF EASGAARVPG TPSVSRGEPR WMSSISTRHN YDESNPMSVA
FRLRHVKDIR KFLRTVRPGR SGFCATDKGG WLGSAAVSDN VIGQGSWGSV HMVKFRDFPE
EFVVKEAVLM SVSEKHRYKP TVVWDEWAAG SVPDEVVVNN MVTEIAATGM TPFVPLTAGA
GACDSCNPQL LEKAAKVTKC YLQAMEAADF SLDRVLPTMS PDQAASALAQ ILLGLQSLQT
TLGIMHNDIK AHNILVKRVP PGGYWKVTDS FNGQVFYIPN EGYLCMLADY GVVRLVKPAV
GMDTLYGTRN ARFVPRDVGR WGKGAGTEYV VTPIRSKISV VVRGGRFVGV EPNKAVRYWK
NTDTSKVGDV ITTNNVFYMG YDIEPDMQVQ LDDTNSFPVW ESRGDVADCV RTFVGGKRAS
QPGFHRLFYK KTGSAWEKAA ETVAKQNPLF SGFTLDGSGL KYIRAATACA YIFPGMAVPR
PGEREIESFT M
//
