ID Q6I6N2_DANRE Unreviewed; 162 AA.
AC Q6I6N2; B3DII7;
DT 19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 152.
DE RecName: Full=Transcription factor MafG {ECO:0000256|ARBA:ARBA00016884};
DE AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog G {ECO:0000256|ARBA:ARBA00030974};
GN Name=mafga {ECO:0000313|Ensembl:ENSDARP00000127969,
GN ECO:0000313|RefSeq:NP_001002045.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040624-7};
GN Synonyms=mafg1 {ECO:0000313|EMBL:AAI63141.1}, sb:eu622
GN {ECO:0000313|RefSeq:NP_001002045.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63141.1};
RN [1] {ECO:0000313|EMBL:BAD24138.1, ECO:0000313|RefSeq:NP_001002045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15207702; DOI=10.1016/j.bbrc.2004.05.131;
RA Takagi Y., Kobayashi M., Li L., Suzuki T., Nishikawa K., Yamamoto M.;
RT "MafT, a new member of the small Maf protein family in zebrafish.";
RL Biochem. Biophys. Res. Commun. 320:62-69(2004).
RN [2] {ECO:0000313|EMBL:AAI63141.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001002045.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19402758;
RA Weil M., Scholz S., Zimmer M., Sacher F., Duis K.;
RT "Gene expression analysis in zebrafish embryos: a potential approach to
RT predict effect concentrations in the fish early life stage test.";
RL Environ. Toxicol. Chem. 28:1970-1978(2009).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000127969, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127969};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000127969}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127969};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001002045.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CU633742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163141; AAI63141.1; -; mRNA.
DR EMBL; BC163157; AAI63157.1; -; mRNA.
DR EMBL; AB167540; BAD24138.1; -; mRNA.
DR RefSeq; NP_001002045.1; NM_001002045.3.
DR STRING; 7955.ENSDARP00000127969; -.
DR PaxDb; 7955-ENSDARP00000111473; -.
DR Ensembl; ENSDART00000154274.2; ENSDARP00000127969.1; ENSDARG00000018109.11.
DR GeneID; 415134; -.
DR KEGG; dre:415134; -.
DR AGR; ZFIN:ZDB-GENE-040624-7; -.
DR CTD; 415134; -.
DR ZFIN; ZDB-GENE-040624-7; mafga.
DR eggNOG; KOG4196; Eukaryota.
DR HOGENOM; CLU_112948_0_0_1; -.
DR OMA; IREQEHP; -.
DR OrthoDB; 2958941at2759; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000018109; Expressed in retina and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IDA:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:ZFIN.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IGI:ZFIN.
DR GO; GO:0045604; P:regulation of epidermal cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd14717; bZIP_Maf_small; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR InterPro; IPR024874; Transcription_factor_Maf_fam.
DR PANTHER; PTHR10129; TRANSCRIPTION FACTOR MAF; 1.
DR PANTHER; PTHR10129:SF15; TRANSCRIPTION FACTOR MAFG; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 51..114
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..110
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 162 AA; 17944 MW; FBE417CEF0314BC4 CRC64;
MTTTNKANKA LKVKREPGEN GTSLTDDELV SMSVRELNQH LRGLTKDEIL QLKQRRRTLK
NRGYAASCRV KRVTQKEELE KQKAELQQEV EKLASENASM KVELDVLRSK YEALQSFART
VARSPVAAAR GPITSVIGPL IPGKVAATSV ITIVKSKTEA RS
//
