ID Q6IG11_RAT Unreviewed; 541 AA.
AC Q6IG11; D3ZV16;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE SubName: Full=Type II keratin Kb21 {ECO:0000313|EMBL:DAA02219.1};
GN Name=Krt81 {ECO:0000313|RGD:1303316};
GN Synonyms=Kb21 {ECO:0000313|RGD:1303316};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:DAA02219.1};
RN [1] {ECO:0000313|EMBL:DAA02219.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BK003974; DAA02219.1; -; mRNA.
DR RefSeq; NP_001008814.1; NM_001008814.1.
DR AlphaFoldDB; Q6IG11; -.
DR SMR; Q6IG11; -.
DR STRING; 10116.ENSRNOP00000012845; -.
DR iPTMnet; Q6IG11; -.
DR PhosphoSitePlus; Q6IG11; -.
DR PaxDb; 10116-ENSRNOP00000063225; -.
DR GeneID; 407761; -.
DR KEGG; rno:407761; -.
DR UCSC; RGD:1303316; rat.
DR AGR; RGD:1303316; -.
DR CTD; 3887; -.
DR RGD; 1303316; Krt81.
DR VEuPathDB; HostDB:ENSRNOG00000036871; -.
DR InParanoid; Q6IG11; -.
DR OrthoDB; 4640531at2759; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR Bgee; ENSRNOG00000036871; Expressed in esophagus.
DR ExpressionAtlas; Q6IG11; baseline and differential.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|RuleBase:RU000685};
KW Keratin {ECO:0000313|EMBL:DAA02219.1}.
FT COILED 159..242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 315..395
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 541 AA; 59312 MW; 82DA41D41C05CE6A CRC64;
MTCGSGFCGR AFSCASACGP RPGRCCITAA PYRGISCYRG LSGGFGSRSV CGAFRSGSCG
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKHEEKEQI KCLNSRFAAF
IDKVRFLEQQ NKLLETKWQF FQNRKCCESN VEPLFEGYIE TLRREAECVE ADSGRLAAEL
NHAQEAMEGY KKRYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANTE ALTQEIDFLR
RLYEEETRIL HAHISDTSVI VKMDNSRDLN MDCVIAEIKA QYDDIASRSR AEAESWYRTK
CEEIKATVIR HGETLRRTRE EINELNRIIQ RLTAEIENAK CQNTKLEAAV TQSEQQGEAA
LTDARCKLAE LEAALQKAKQ DMACLLKEYQ EVMNSKLGLD IEIATYRHLL EGEEQRLCEG
VGAVNVCVSS SRGGVVCGDL CVSGSRPVTG SACSAPCSGN LAVNTGLCAP CGSAVSCGRK
CKLPSHPGPF IAFHPESSLA DQYWDLEEGT QPLAHFEMTL TLGPSGLPGG PPLLSEVNTG
F
//
