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Database: UniProt
Entry: Q6IMH6_MOUSE
LinkDB: Q6IMH6_MOUSE
Original site: Q6IMH6_MOUSE 
ID   Q6IMH6_MOUSE            Unreviewed;       699 AA.
AC   Q6IMH6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   18-SEP-2019, entry version 131.
DE   SubName: Full=A disintegrin and metallopeptidase domain 26B {ECO:0000313|Ensembl:ENSMUSP00000079032};
DE   SubName: Full=ADAM26b {ECO:0000313|EMBL:DAA01539.1};
GN   Name=Adam26b {ECO:0000313|Ensembl:ENSMUSP00000079032,
GN   ECO:0000313|MGI:MGI:3588304};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:DAA01539.1};
RN   [1] {ECO:0000313|EMBL:DAA01539.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15028286; DOI=10.1016/j.ygeno.2003.10.001;
RA   Choi I., Oh J., Cho B.N., Ahnn J., Jung Y.K., Han Kim D., Cho C.;
RT   "Characterization and comparative genomic analysis of intronless Adams
RT   with testicular gene expression.";
RL   Genomics 83:636-646(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000079032, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079032,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000079032}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079032};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC134907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK001468; DAA01539.1; -; Genomic_DNA.
DR   RefSeq; NP_001009547.1; NM_001009547.2.
DR   STRING; 10090.ENSMUSP00000079032; -.
DR   DNASU; 382007; -.
DR   Ensembl; ENSMUST00000080135; ENSMUSP00000079032; ENSMUSG00000063900.
DR   GeneID; 382007; -.
DR   KEGG; mmu:382007; -.
DR   UCSC; uc009loe.1; mouse.
DR   CTD; 382007; -.
DR   MGI; MGI:3588304; Adam26b.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000162672; -.
DR   HOGENOM; HOG000230883; -.
DR   OMA; QCERIND; -.
DR   OrthoDB; 162519at2759; -.
DR   TreeFam; TF314733; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   Bgee; ENSMUSG00000063900; Expressed in 4 organ(s), highest expression level in testis.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00877335};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    699       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015098317.
FT   TRANSMEM    671    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      195    385       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      392    478       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      616    649       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    450    470       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    639    648       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   699 AA;  78986 MW;  C280D547E0DE43E8 CRC64;
     MFLKFCLWTM FFFSAWSPIG HAKYSSLPEV VTPLRVTVTR GNNTSPGWLS YSLNIGGQRH
     IITMKPKKNL MSRNLILLTY TQQGDLLEQR PFVPNDCYYH GYVDEDPESL VILNTCFGSL
     QGTLEINGTT YEIMPKSSTS TFEHLAYKMD NGDSEPSPMR CGLSEEEIAQ QRKLRERNAP
     TLLQIPHENW WTHHRFIEYF VVIDHKQYVH RNNNITTCIQ DMLQIVNGVN GYYLQIDTDV
     VLTALEIWNE KNYINVELSI FKVLGDFCTW KQNMFGNRIR HDIIHLLVRQ GYGLYLGLAY
     LADVCTPYNC GVSSFLSDVM SDMAHIVAHE MGHNLGMKHD GIGCTCGLKD CLMAPYKTNS
     PKFSNCSYEE MYSVVTKRSC LYDIPEALVT NLTVCGNKVV EEGEECDCGS TESCLQDPCC
     SSDCVLKPGA QCAFGLCCQD CQFLKTGTVC REEKNECDLP EWCNGTSAEC PGDVYKADGI
     PCSGEGYCYK MECHQRDEQC RKIFGNGSRS ADEICYMEMN RRGDRFGNCG NDSSKYKICE
     LADVLCGRIQ CENVIQLPQR RNHETVHYTH FSNVTCWTMD YHFGITIDDI GAVSDGTACA
     PYHICVDRKC VSKSDLVSNC TTKLCHMQGV CNNKNHCHCT NTWEPPDCQL RGHGGSLDSG
     PPPLHVPNSS WAFYFISFFT ILLVITISLV GITKRVKMN
//
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