ID Q6INB1_XENLA Unreviewed; 122 AA.
AC Q6INB1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Glycoprotein hormones alpha chain {ECO:0000256|RuleBase:RU362129};
GN Name=cga.L {ECO:0000313|RefSeq:NP_001085173.1,
GN ECO:0000313|Xenbase:XB-GENE-865183};
GN Synonyms=cg-alpha {ECO:0000313|RefSeq:NP_001085173.1}, cga
GN {ECO:0000313|RefSeq:NP_001085173.1,
GN ECO:0000313|Xenbase:XB-GENE-865183}, cga-a
GN {ECO:0000313|RefSeq:NP_001085173.1}, cga-b
GN {ECO:0000313|RefSeq:NP_001085173.1}, fsha
GN {ECO:0000313|RefSeq:NP_001085173.1}, gpha
GN {ECO:0000313|RefSeq:NP_001085173.1}, gpha1
GN {ECO:0000313|RefSeq:NP_001085173.1}, hcg
GN {ECO:0000313|RefSeq:NP_001085173.1}, lha
GN {ECO:0000313|RefSeq:NP_001085173.1}, MGC84501
GN {ECO:0000313|EMBL:AAH72372.1}, tsha
GN {ECO:0000313|RefSeq:NP_001085173.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH72372.1};
RN [1] {ECO:0000313|RefSeq:NP_001085173.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH72372.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye {ECO:0000313|EMBL:AAH72372.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085173.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC {ECO:0000256|RuleBase:RU362129}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU362129}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC {ECO:0000256|ARBA:ARBA00009128, ECO:0000256|RuleBase:RU362129}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC072372; AAH72372.1; -; mRNA.
DR RefSeq; NP_001085173.1; NM_001091704.1.
DR STRING; 8355.Q6INB1; -.
DR PaxDb; 8355-Q6INB1; -.
DR DNASU; 432256; -.
DR GeneID; 432256; -.
DR KEGG; xla:432256; -.
DR AGR; Xenbase:XB-GENE-865183; -.
DR CTD; 432256; -.
DR Xenbase; XB-GENE-865183; cga.L.
DR OMA; KHSHETI; -.
DR OrthoDB; 4182331at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 432256; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000476; Glyco_hormone.
DR PANTHER; PTHR11509; GLYCOPROTEIN HORMONE ALPHA CHAIN; 1.
DR PANTHER; PTHR11509:SF0; GLYCOPROTEIN HORMONES ALPHA CHAIN; 1.
DR Pfam; PF00236; Hormone_6; 1.
DR PRINTS; PR00274; GLYCOHORMONE.
DR SMART; SM00067; GHA; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|RuleBase:RU362129};
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU362129};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|RuleBase:RU362129};
KW Signal {ECO:0000256|RuleBase:RU362129, ECO:0000313|RefSeq:NP_001085173.1}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU362129"
FT CHAIN 25..122
FT /note="Glycoprotein hormones alpha chain"
FT /evidence="ECO:0000256|RuleBase:RU362129,
FT ECO:0000313|RefSeq:NP_001085173.1"
FT /id="PRO_5033206739"
SQ SEQUENCE 122 AA; 13837 MW; A2212D1A60E1DC02 CRC64;
MDYCGKYIAV ILAFIFVFMH VLHSFPEGDL MVQGCPECKL KENTYFTKRL GKALIFQCTG
CCFSRAYPTP MRSKKTMLVP KNITSEATCC VAKASTRVTV IDNLKIENHT DCHCSTCYYH
KS
//
