ID Q6IP34_XENLA Unreviewed; 190 AA.
AC Q6IP34;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Neuronal calcium sensor 1 {ECO:0000256|ARBA:ARBA00039972};
GN Name=ncs1.S {ECO:0000313|RefSeq:NP_001085136.1,
GN ECO:0000313|Xenbase:XB-GENE-17342716};
GN Synonyms=flup {ECO:0000313|RefSeq:NP_001085136.1}, freq
GN {ECO:0000313|RefSeq:NP_001085136.1}, frequenin
GN {ECO:0000313|RefSeq:NP_001085136.1}, MGC78985
GN {ECO:0000313|EMBL:AAH72084.1}, ncs-1
GN {ECO:0000313|RefSeq:NP_001085136.1}, ncs1
GN {ECO:0000313|Xenbase:XB-GENE-17342716}, xfreq
GN {ECO:0000313|RefSeq:NP_001085136.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH72084.1};
RN [1] {ECO:0000313|RefSeq:NP_001085136.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH72084.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI60777.1}, and Embryo
RC {ECO:0000313|EMBL:AAH72084.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001085136.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
CC -!- SIMILARITY: Belongs to the recoverin family.
CC {ECO:0000256|ARBA:ARBA00006049}.
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DR EMBL; BC072084; AAH72084.1; -; mRNA.
DR EMBL; BC160777; AAI60777.1; -; mRNA.
DR RefSeq; NP_001085136.1; NM_001091667.1.
DR STRING; 8355.Q6IP34; -.
DR PaxDb; 8355-Q6IP34; -.
DR DNASU; 432213; -.
DR GeneID; 432213; -.
DR KEGG; xla:432213; -.
DR AGR; Xenbase:XB-GENE-17342716; -.
DR Xenbase; XB-GENE-17342716; ncs1.S.
DR OMA; EYVFNVF; -.
DR OrthoDB; 339700at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 432213; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028846; Recoverin.
DR PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1.
DR PANTHER; PTHR23055:SF195; NEURONAL CALCIUM SENSOR 1; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 60..95
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 96..131
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 144..179
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 190 AA; 21894 MW; 3698E264CD181080 CRC64;
MGKSNSKLKP EVVEELTRKT YFTEKEVQQW YKGFIKDCPS GQLDAAGFQK IYKQFFPFGD
PTKFATFVFN VFDENKDGRI EFSEFIQALS VTSRGTLDEK LRWAFKLYDL DNDGYITRNE
MLNIVDAIYQ MVGNTVELPE EENTPEKRVD RIFAMMDKNS DGKLTLQEFQ EGSKADPSIV
QALSLYDGLV
//
